14 October 2025 : Original article
Long-Term Outcomes of Combined Hepatocellular Carcinoma-Cholangiocarcinoma After Liver Transplantation in Patients with or without Concurrent Hepatocellular Carcinoma
I-Ji Jeong
CEF 1, Shin Hwang ACDEF 1*, Chul-Soo Ahn BCF 1, Deok-Bog Moon BCF 1, Tae-Yong Ha BC 1, Gi-Won Song BCD 1, Dong-Hwan Jung BCD 1, Gil-Chun Park BC 1, Woo-Hyoung Kang BC 1, Young-In Yoon BC 1, Sung-Gyu Lee ABC 1
DOI: 10.12659/AOT.951088
Ann Transplant 2025; 30:e951088
Table 2 Multivariate analysis, based on the 8th edition AJCC stages, of patients with combined hepatocellular carcinoma-cholangiocarcinoma (CHC) and concurrent hepatocellular carcinoma (HCC) who underwent liver transplantation.
| Variable | Tumor recurrence | Patient survival | ||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | p-value | Hazard ratio | 95% CI | p-value | |
| CHC stage | ||||||
| IA & IB | 1 | 1 | ||||
| II & IIIA | 7.14 | 1.56–32.25 | 0.011 | 3.17 | 0.93–10.75 | 0.046 |
| Concurrent HCC stage | ||||||
| IA & IB | 1 | 1 | ||||
| II & IIIA | 1.55 | 0.36–6.67 | 0.554 | 1.05 | 0.33–3.39 | 0.924 |
| AJCC – American Joint Committee on Cancer tumor staging system; CI – confidence interval. | ||||||