A Retrospective Study of 518 Kidney Transplant Recipients to Evaluate the Association of Antiplatelet Therapy With Long-Term Cardiovascular Events and All-Cause Mortality

Gavin Christy; Andres Mata; Zalan Shah; Ananta M.H. Sriram; Diana Pfeiffer; Taylor R. Coffman; Madeline K. Johnson; Sahita Gandra; Krista L. Lentine; Mina M. Benjamin

doi:10.12659/AOT.951325

12 May 2026 : Original article

A Retrospective Study of 518 Kidney Transplant Recipients to Evaluate the Association of Antiplatelet Therapy With Long-Term Cardiovascular Events and All-Cause Mortality

Gavin Christy^{BCEF 1}, Andres Mata^{ABE 2}, Zalan Shah^{B 1}, Ananta M.H. Sriram^{B 1}, Diana Pfeiffer^{B 1}, Taylor R. Coffman

^{B 1}, Madeline K. Johnson^{E 1}, Sahita Gandra^{E 1}, Krista L. Lentine

^{ADEG 3}, Mina M. Benjamin

^{ADE 4*}

DOI: 10.12659/AOT.951325

Ann Transplant 2026; 31:e951325

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Table 4 Univariate logistic regression analysis for the association between baseline variables and (1) the composite of major adverse cardiovascular events and all-cause mortality and (2) major adverse cardiovascular events alone in 518 kidney transplant recipients.

Variable	MACE+all-cause mortality			MACE
Variable	Odds ratio	95% CI	P value	Odds ratio	95% CI	P value
Age	1.03	1.01–1.04	0.002	1.02	1.00–1.04	0.03
Male sex	1.21	0.81–1.81	0.34	1.34	0.79–2.29	0.28
Body mass index	1.01	0.97–1.04	0.62	0.81	0.35–1.86	0.61
Smoking	1.09	0.74–1.60	0.66	1.32	0.79–2.20	0.29
Hemodialysis	1.91	1.25–2.93		1.75	1.01–3.04
Antiplatelet therapy	1.08	0.72–1.61	0.72	1.21	0.71–2.06	0.49
Coronary artery disease	2.97	1.96–4.52		2.94	1.86–4.64
Cerebrovascular disease	1.97	0.79–4.92	0.15	9.33	1.67–52.12
Diabetes mellitus	1.89	1.27–2.83		0.81	0.35–1.86	0.61
Obstructive sleep apnea	1.33	0.87–2.03	0.19	1.19	0.65–2.15	0.57
Hypertension	0.76	0.39–1.48	0.43	0.81	0.35–1.86	0.61
Aortic regurgitation	1.28	0.61–2.69	0.50	0.88	0.29–2.67	0.82
Myocardial infarction	5.76	2.09–15.92		1.94	0.46–7.31	0.39
Arrhythmic event	1.26	0.47–2.34	0.645	1.01	0.97–1.06	0.51
Post-transplant serum creatinine	0.95	0.72–1.26	0.73	0.67	0.43–1.06	0.09
CI – confidence interval; MACE – major adverse cardiovascular events.

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A Retrospective Study of 518 Kidney Transplant Recipients to Evaluate the Association of Antiplatelet Therapy With Long-Term Cardiovascular Events and All-Cause Mortality

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