03 February 2026 : Original article
Diagnostic Utility of FAR1 Methylation Levels in Hepatocellular Carcinoma Patients Undergoing Liver Transplantation
Byeong-Gon Na
BCE 1, Shin Hwang ABCDEF 1*, Jinil Han BCD 2, Dong-Hwan Jung BCD 1, Gi-Won Song BCD 1, Yun Young Lee BCD 2, Eunyoung Tak BCD 3, Kyoung-Jin Lee BCD 3, Yun-Kyu Kim BCD 3
DOI: 10.12659/AOT.951568
Ann Transplant 2026; 31:e951568
Table 3 Comparison of receiver operating characteristic (ROC) curve analysis results for FAR1 methylation, AFP, and PIVKA-II.
| Marker | ROC AUC | Youden index | At conventional cut-off | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC | 95% CI | p-value | Youden index J | Cut-off | Sensitivity | Specificity | Cut-off value | Sensitivity | Specificity | pLR | nLR | |
| FAR1 | 0.832 | 0.691–0.927 | <0.001 | 0.599 | One copy | 82.6% | 77.3% | Two copies | 56.5% | 86.4% | 4.14 | 0.50 |
| AFP | 0.737 | 0.585–0.857 | 0.002 | 0.466 | 4.1 ng/mL | 73.9% | 72.7% | 7.5 ng/mL | 43.5% | 86.4% | 3.19 | 0.65 |
| PIVKA-II | 0.731 | 0.578–0.852 | 0.003 | 0.474 | 31 mAU/mL | 56.5% | 90.9% | 40 mAU/mL | 34.8% | 90.9% | 3.83 | 0.72 |
| AUC – area under the ROC curve; 95% CI – 95% confidence interval; AFP – α-fetoprotein; PIVKA-II – protein induced by vitamin K absence or antagonist-II; pLR – positive likelihood ratio; nLR – negative likelihood ratio. | ||||||||||||