09 June 2026 : Original article
Brain Death–Induced Systolic Ventricular Dysfunction and Its Association With NLRP3-Related Inflammatory Signaling in a Murine Model
Lei Huang ABCDEFG 1,2, Kevin P. Zbierski B 3, Ye Yuan CD 2, Siyuan Dong CD 2, Jacob Razzouk C 3, David G. Rabkin
ABCDEFG 3*
DOI: 10.12659/AOT.951930
Ann Transplant 2026; 31:e951930
Table 1 Phase I baseline characteristics.
| Control (n=8) | Brain death (n=10) | P value | |
|---|---|---|---|
| Weight (g) | 28.63±3.46 | 28.60±2.27 | 0.986 |
| Temperature (°C) | 32.89±0.75 | 32.88±0.63 | 0.977 |
| LV aread (mm) | 15.66±4.00 | 18.63±3.99 | 0.138 |
| LV areas (mm) | 9.00±2.09 | 10.75±2.79 | 0.160 |
| CO (mL/min) | 8.52±1.70 | 9.88±1.86 | 0.155 |
| LVEF (%) | 63.3±4.93 | 59.4±5.92 | 0.164 |
| FS (%) | 16.1±4.70 | 19.7±5.25 | 0.153 |
| SV (μL) | 24.7±5.07 | 25.7±3.21 | 0.692 |
| Vold (μL) | 41.1±11.8 | 42.3±9.80 | 0.852 |
| Vols (μL) | 15.3±5.31 | 16.8±8.20 | 0.714 |
| Heart rate (bpm) | 389±48.5 | 366±37.4 | 0.298 |
| Data are reported as mean±standard deviation. area, – area in diastole; area – area in systole; CO – cardiac output; LV – left ventricle; LVEF – left ventricular ejection fraction; FS – fractional shortening; SV – stroke volume. | |||