09 June 2026 : Original article
Brain Death–Induced Systolic Ventricular Dysfunction and Its Association With NLRP3-Related Inflammatory Signaling in a Murine Model
Lei Huang ABCDEFG 1,2, Kevin P. Zbierski B 3, Ye Yuan CD 2, Siyuan Dong CD 2, Jacob Razzouk C 3, David G. Rabkin
ABCDEFG 3*
DOI: 10.12659/AOT.951930
Ann Transplant 2026; 31:e951930
Table 2 Phase 2 baseline characteristics.
| Control (n=6) | Brain death (n=6) | P value | |
|---|---|---|---|
| Weight (g) | 27.7±2.9 | 27.3±3.0 | 0.819 |
| Temperature (°C) | 33.0±1.0 | 33.1±0.7 | 0.845 |
| LV aread (mm) | 17.3±5.3 | 17.5±2.6 | 0.936 |
| LV areas (mm) | 9.3±3.1 | 9.9±2.3 | 0.711 |
| CO (mL/min) | 9.2±2.5 | 9.2±1.8 | 1.00 |
| LVEF (%) | 63.2±8.9 | 62.6±3.9 | 0.883 |
| FS (%) | 14.5±2.9 | 16.8±3.4 | 0.236 |
| SV (μL) | 25.9±12.9 | 25.7±3.2 | 0.971 |
| Vold (μL) | 40.5±17.8 | 43.3±8.8 | 0.737 |
| Vols (μL) | 16.4±15.3 | 17.8±9.1 | 0.811 |
| Heart rate (bpm) | 414±69.5 | 358±54.3 | 0.159 |
| Data are reported as mean±standard deviation. area – area in diastole; area – area in systole; CO – cardiac output; LV – left ventricle; LVEF – left ventricular ejection fraction; FS – fractional shortening; SV – stroke volume. | |||