16 June 2026 : Database Analysis
Opioid-Sparing Effects of Peripheral Nerve Blocks in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis
Hye Joo Yun ABCDEF 1, Dong Hyun Kim CDEF 1, Mee Young Chung ABCDEFG 1, Ji Young Min
ABCDEF 1*
DOI: 10.12659/AOT.952211
Ann Transplant 2026; 31:e952211
Table 3 Summary of meta-analysis results for outcomes.
| Outcome | n | Pooled MD (95% CI) | P value | Heterogeneity | Copas selection model (95% CI) |
|---|---|---|---|---|---|
| 24-hour morphine consumption (overall) | 10 | −16.20 mg (−24.66 to −7.74) | 0.0002* | Q=691.40 df=9, <0.001;=99%, τ=182.33 | MD=−16.22 mg (95% CI −25.59 to −6.85; P=0.0007) |
| 24-hour morphine consumption (TAP subgroup) | 6 | −12.13 mg (−20.24 to −4.03) | 0.0033* | Q=244.26, df=5, <0.001;=98%, τ=99.10 | MD=−12.14 mg (95% CI −20.42 to −3.86; P=0.004) |
| 24-hour resting VAS score | 5 | −1.49 (−1.97 to −1.01) | <0.001* | Q=4.90, df=4, =0.30;=18%, τ=0.056 | MD=−1.45 mg (95% CI −1.88 to −1.02; <0.001) |
| This table summarizes the pooled quantitative results of the included studies evaluating the effect of peripheral nerve blocks (PNBs) on postoperative analgesia in kidney transplantation. The random-effects model (DerSimonian-Laird method) was used to calculate pooled mean differences (MDs) and 95% confidence intervals (CIs). Heterogeneity was assessed using the Q statistic, , and τ. For publication bias, adjusted estimates using the Copas selection model are presented when available. * MD – mean difference; CI – confidence interval; VAS – visual analog scale; TAP – transversus abdominis plane. | |||||