14 July 2026 : Original article
iTRAQ- and MRM-Based Proteomics Identify Early Injury Biomarkers for Primary Dysfunction After Liver Transplantation
Xiaohong Lin ABCE 1,2, Wanzhen Cai ABCE 3, Xitao Hong ABCE 1, Ziming Ye BC 3, Yuqi Dong
BC 1, Shuai Wang CD 1, Xiaoshun He ADFG 1, Donghong Li CDE 4, Weiqiang Ju ADG 1*, Maogen Chen ADEFG 1
DOI: 10.12659/AOT.952366
Ann Transplant 2026; 31:e952366
Table 1 Clinical characteristics of donors, recipients and transplantation procedures.
| Characteristics | Control (n=5) | OG (n=5) | EAD (n=5) | PNF (n=5) | P value |
|---|---|---|---|---|---|
| Sex, M/F (% male) | 4/1 (80%) | 4/1 (80%) | 3/2 (60%) | 4/1 (80%) | 1.000 |
| Age, median (median and range) | 37.8 (13–64) | 22.2 (13–46) | 35.8 (19–49) | 34.4 (24–43) | 0.342 |
| BMI (mean±SD) | 21.2±2.74 | 20.92±1.73 | 23.4±1.68 | 23.8±2.56 | 0.986 |
| ICU stay, days (median and range) | 3.2 (1–7) | 3.2 (2–7) | 2.7 (1–6) | 3.3 (3–7) | 0.918 |
| Steatosis macrovesicular >10% (%) | 0% | 0% | 20% | 20% | 1.000 |
| HBsAg (+) (%) | 20% | 0% | 20% | 0% | 1.000 |
| CIT, min (median and range) | 471 (289–651) | 389 (282–540) | 487 (390–582) | 539 (360–714) | 0.062 |
| Donation type, DBD/DCD (% of DBD) | 5/0 (100%) | 4/1 (80%) | 4/1 (80%) | 3/2 (60%) | 0.472 |
| Sex M/F (% of male) | 4/1 (80%) | 5/0 (100%) | 5/0 (100%) | 4/1 (80%) | 0.472 |
| Age, median (median and range) | 50.8 (38–67) | 53.2 (46–61) | 47.6 (34–55) | 51.6 (29–67) | 0.682 |
| BMI (mean±SD) | 23.7±3.38 | 24.2±3.70 | 26.2±1.25 | 20.7±2.21 | 0.056 |
| Lab MELD score at transplantation (mean±SD) | 17.4±7.1 | 16.6±13.1 | 14.8±7.7 | 26.8±12.8 | 0.573 |
| Child-Pugh points, A/B/C | 3/2/0 | 2/2/1 | 2/3/0 | 2/1/2 | 0.576 |
| WIT, min (median and range) | NA | 6 (6) | 3 (3) | 10 (8–12) | NA |
| 100% | 100% | 100% | 0% | ||
| 100% | 100% | 100% | 0% | ||
| 0% | 0% | 0% | 100% | ||
| ICU stay, days (median and range) | 4 (2–10) | 4 (2–7) | 4 (2–7) | 6 (3–9) | 0.745 |