14 July 2026 : Original article
iTRAQ- and MRM-Based Proteomics Identify Early Injury Biomarkers for Primary Dysfunction After Liver Transplantation
Xiaohong Lin ABCE 1,2, Wanzhen Cai ABCE 3, Xitao Hong ABCE 1, Ziming Ye BC 3, Yuqi Dong
BC 1, Shuai Wang CD 1, Xiaoshun He ADFG 1, Donghong Li CDE 4, Weiqiang Ju ADG 1*, Maogen Chen ADEFG 1
DOI: 10.12659/AOT.952366
Ann Transplant 2026; 31:e952366
Table 2 Top 20 pathways in KEGG pathway analysis of the liver proteome datasets after reperfusion.
| Rank | OG group | EAD group | PNF group |
|---|---|---|---|
| Histidine metabolism | Biosynthesis of amino acids | Metabolic pathways | |
| Measles | Complement and coagulation cascades | Carbon metabolism | |
| Amoebiasis | Metabolic pathways | Biosynthesis of amino acids | |
| Transcriptional misregulation in cancer | Nitrogen metabolism | Glycolysis/gluconeogenesis | |
| Staphylococcus aureus infection | Carbon metabolism | Glyoxylate and dicarboxylate metabolism | |
| Fat digestion and absorption | Glyoxylate and dicarboxylate metabolism | Fatty acid degradation | |
| Proximal tubule bicarbonate reclamation | Citrate cycle (TCA cycle) | Arginine biosynthesis | |
| Proteasome | Proximal tubule bicarbonate reclamation | Tyrosine metabolism | |
| Fc gamma R-mediated phagocytosis | Arginine biosynthesis | Citrate cycle (TCA cycle) | |
| IL-17 signaling pathway | Pathogenic Escherichia coli infection | Amino sugar and nucleotide sugar metabolism | |
| Systemic lupus erythematosus | 2-Oxocarboxylic acid metabolism | 2-Oxocarboxylic acid metabolism | |
| Mineral absorption | Glutathione metabolism | Pentose phosphate pathway | |
| Ascorbate and aldarate metabolism | Fluid shear stress and atherosclerosis | Fructose and mannose metabolism | |
| Metabolic pathways | Butanoate metabolism | Retinol metabolism | |
| Pentose and glucuronate interconversions | beta-Alanine metabolism | Ribosome | |
| PPAR signaling pathway | Glycosaminoglycan biosynthesis - heparan sulfate/heparin | Glycine, serine and threonine metabolism | |
| Neuroactive ligand-receptor interaction | Vitamin B6 metabolism | Peroxisome | |
| Insect hormone biosynthesis | Glycosaminoglycan biosynthesis – chondroitin sulfate/dermatan sulfate | Complement and coagulation cascades | |
| Glycerolipid metabolism | Protein processing in endoplasmic reticulum | Butanoate metabolism | |
| Glyoxylate and dicarboxylate metabolism | Cardiac muscle contraction | One carbon pool by folate |