iTRAQ- and MRM-Based Proteomics Identify Early Injury Biomarkers for Primary Dysfunction After Liver Transplantation

14 July 2026 : Original article

Xiaohong Lin^{ABCE 1,2}, Wanzhen Cai^{ABCE 3}, Xitao Hong^{ABCE 1}, Ziming Ye^{BC 3}, Yuqi Dong

^{BC 1}, Shuai Wang^{CD 1}, Xiaoshun He^{ADFG 1}, Donghong Li^{CDE 4}, Weiqiang Ju^{ADG 1*}, Maogen Chen^{ADEFG 1}

DOI: 10.12659/AOT.952366

Ann Transplant 2026; 31:e952366

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Table 4 MRM validation of differentially expressed proteins identified by iTRAQ.

Protein symbol	iTRAQ Fold change (±SD)	MRM Fold change (±SEM)	Log2 Fold change	95% CI	MRM FDR	PNF2 vs control
	0.64±0.20	0.39±0.13	−1.36	[0.15, 0.80]	<0.001	Downregulation
	0.68±0.09	0.24±0.12	−2.06	[0.02, 0.58]	0.00134	Downregulation
	0.64±0.10	0.36±0.14	−1.47	[0.04, 0.71]	0.00143	Downregulation
	0.62±0.22	0.32±0.10	−1.64	[0.09, 0.55]	0.00127	Downregulation
	0.77±0.12	0.39±0.12	−1.36	[0.15, 0.72]	0.00128	Downregulation
	1.54±0.45	0.86±0.16	−0.22	[0.44, 1.23]	0.531	Downregulation
	2.11±1.07	2.21±0.57	1.14	[1.28, 3.95]	0.00206	Upregulation
	1.52±0.18	1.74±0.50	0.80	[0.40, 2.99]	0.211	Upregulation
	1.4±0.19	1.03±0.33	0.04	[0.26, 1.91]	0.933	Upregulation
	2.3±1.19	1.97±0.49	0.98	[0.65, 2.93]	0.154	Upregulation
All comparisons were performed using the test (2-tailed, df=8). FDR0.05 means a significant difference.

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