14 July 2026 : Original article
iTRAQ- and MRM-Based Proteomics Identify Early Injury Biomarkers for Primary Dysfunction After Liver Transplantation
Xiaohong Lin ABCE 1,2, Wanzhen Cai ABCE 3, Xitao Hong ABCE 1, Ziming Ye BC 3, Yuqi Dong
BC 1, Shuai Wang CD 1, Xiaoshun He ADFG 1, Donghong Li CDE 4, Weiqiang Ju ADG 1*, Maogen Chen ADEFG 1
DOI: 10.12659/AOT.952366
Ann Transplant 2026; 31:e952366
Table 5 Functions and localization of the verified proteins by MRM.
| Probe set ID | Protein symbol | Description | Subcellular localization | Function | PNF2 vs control |
|---|---|---|---|---|---|
| Peroxiredoxin-1 | Cytoplasmic/nucleus | Oxidative stress; cell proliferation; energy metabolism | Downregulation | ||
| Homogentisate 1,2-dioxygenase | Nucleus | Oxidative stress; metal ion binding; energy metabolism | Downregulation | ||
| Thioredoxin | Nucleus/mitochondrial | Oxidative stress; cell proliferation; energy metabolism | Downregulation | ||
| 4-hydroxyphenylpyruvate dioxygenase | Nucleus | Oxidative stress; metal ion binding; production of no; energy metabolism | Downregulation | ||
| 6-phosphogluconate dehydrogenase | Cyto_pero/nucleus | Energy metabolism | Downregulation | ||
| Succinate dehydrogenase [ubiquinone] iron-sulfur subunit | Mitochondrial | Metal ion binding; energy metabolism | Downregulation | ||
| Von Willebrand factor | Extracellular | Cell adhesion; blood coagulation | Upregulation | ||
| Glycine amidinotransferase | Mitochondrial | Oxidative stress; energy metabolism | Upregulation | ||
| Propionyl-CoA carboxylase beta chain | Mitochondrial | Fatty acid metabolism | Upregulation | ||
| Thrombospondin-1 | Nucleus/cyto_pero mitochondrial | Oxidative stress; fatty acid metabolism; calcium ion binding; immune response; energy metabolism; cell proliferation | Upregulation |