Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus

Shun Nishioka; Takeshi Ishimura; Takahito Endo; Naoki Yokoyama; Satoshi Ogawa; Masato Fujisawa

doi:10.12659/AOT.926476

12 January 2021 : Original article

Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus

Shun Nishioka^1ABCDE, Takeshi Ishimura^1ACDE*, Takahito Endo^1B, Naoki Yokoyama^1BC, Satoshi Ogawa^1BCD, Masato Fujisawa^1E

DOI: 10.12659/AOT.926476

Ann Transplant 2021; 26:e926476

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Figure 2 Trough concentrations of Tac and EVR in the EVR+ and EVR− groups. (A) The trough concentration of Tac in the EVR+ group ( – closed circles) was significantly lower than in the EVR− group ( – open circles) at 6, 9, 12, 15 months, and 3 years after kidney transplantation (* P<0.001). (B) The trough concentration of EVR was in the range of 5–8 ng/ml at all times. C0 – trough concentration; Tac – tacrolimus; EVR – everolimus.

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Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus

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