12 January 2021>: Original Paper
Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus
Shun Nishioka ABCDE , Takeshi Ishimura ACDE* , Takahito Endo B , Naoki Yokoyama BC , Satoshi Ogawa BCD , Masato Fujisawa EDOI: 10.12659/AOT.926476
Ann Transplant 2021; 26:e926476
Figure 2 Trough concentrations of Tac and EVR in the EVR+ and EVR− groups. (A) The trough concentration of Tac in the EVR+ group ( – closed circles) was significantly lower than in the EVR− group ( – open circles) at 6, 9, 12, 15 months, and 3 years after kidney transplantation (* P<0.001). (B) The trough concentration of EVR was in the range of 5–8 ng/ml at all times. C0 – trough concentration; Tac – tacrolimus; EVR – everolimus.