12 January 2021: Original Paper
Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus
Shun Nishioka ABCDE , Takeshi Ishimura ACDE* , Takahito Endo B , Naoki Yokoyama BC , Satoshi Ogawa BCD , Masato Fujisawa EDOI: 10.12659/AOT.926476
Ann Transplant 2021; 26:e926476
Figure 3 Change in eGFR and FI after kidney transplantation in the EVR+ and EVR− groups. (A) eGFR values in the EVR+ group ( – closed circles) and EVR− group ( – open circles) from 3 months to 3 years after KTx. Declines in eGFR from 3 months to 3 years after KTx (ΔeGFR=eGFR at 3 years–eGFR at 3 months) in the EVR+ group were significantly less than those in the EVR− group (P<0.001). (B) The extent of fibrosis (FI) in the EVR+ group ( – closed circles) and EVR− group ( – open circles) from 3 months to 3 years after KTx. The progression of fibrosis (ΔFI=FI at 3 years–FI at 3 months) in the EVR− group was significantly greater than in the EVR+ group (P<0.001). eGFR – estimated-glomerular filtration rate (ml/min/1.73 m2); FI – fibrosis index (%), KTx – kidney transplantation; EVR – everolimus.