Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus

Shun Nishioka; Takeshi Ishimura; Takahito Endo; Naoki Yokoyama; Satoshi Ogawa; Masato Fujisawa

doi:10.12659/AOT.926476

12 January 2021 : Original article

Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus

Shun Nishioka^1ABCDE, Takeshi Ishimura^1ACDE*, Takahito Endo^1B, Naoki Yokoyama^1BC, Satoshi Ogawa^1BCD, Masato Fujisawa^1E

DOI: 10.12659/AOT.926476

Ann Transplant 2021; 26:e926476

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Figure 4 Representative images of immunohistochemical staining (scores 0–3 of p-mTOR staining). Positive staining was mainly observed in the cytoplasm of renal proximal and distal tubules, and slightly in glomeruli (magnification: ×200). p-mTOR – phosphorylated mammalian target of rapamycin.

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Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus

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