12 January 2021: Original Paper
Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus
Shun Nishioka ABCDE , Takeshi Ishimura ACDE* , Takahito Endo B , Naoki Yokoyama BC , Satoshi Ogawa BCD , Masato Fujisawa EDOI: 10.12659/AOT.926476
Ann Transplant 2021; 26:e926476
Figure 5 Mean staining score of each protein at 3 months and 3 years after KTx in the EVR+ and EVR− groups. The staining scores of all 5 proteins at 3 months after KTx were similar in EVR+ () and EVR− () groups. The p-mTOR staining score in the EVR+ group was significantly decreased from 3 months to 3 years after KTx (* P=0.028). For p-mTOR and p-4EBP, the staining scores at 3 years after KTx were higher in the EVR− group than in the EVR+ group (** P<0.01, *** P<0.01, respectively). 3m – 3 months after kidney transplantation; 3y – 3 years after kidney transplantation; p-Akt – phosphorylated Akt; Rheb – Ras homolog enriched in brain; p-mTOR – phosphorylated mammalian target of rapamycin; p-p70S6K – phosphorylated p70 ribosomal S6 kinase; p-4EBP1 – phosphorylated 4E-binding protein 1.