Figure 5 Histopathologic changes in bone marrow and splenic hematopoietic tissue after amniotic fluid transplantation. (A) Bone marrow from a normal healthy animal. (B) Bone marrow from an aplastic anemia rat; the hematopoietic cells significantly decreased compared to normal healthy animal. (C) Bone marrow from an aplastic anemia rat post amniotic fluid transplantation. The number of hematopoietic cells was very similar to that in healthy animals. (D) Splenic hematopoietic tissue from a normal healthy animal. (E) Splenic hematopoietic tissue from an aplastic anemia animal; compensatory extramedullary hematopoiesis was active. (F) Splenic hematopoietic tissue from an aplastic anemia rat after amniotic fluid transplantation; there was no obvious extramedullary hematopoiesis.