Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d⁺ Antibody-Mediated Rejection in Kidney Transplant Recipients

Vasishta S. Tatapudi; Dessislava Kopchaliiska; Gilberto J. da Gente; Owen F. Buenaventura; Manpreet Singh; Zoltan Laszik; Deborah B. Adey; Raja Rajalingam

doi:10.12659/AOT.934175

01 December 2021 : Original article

Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d⁺ Antibody-Mediated Rejection in Kidney Transplant Recipients

Vasishta S. Tatapudi^1BDEF, Dessislava Kopchaliiska^2ABC, Gilberto J. da Gente^2C, Owen F. Buenaventura^2BC, Manpreet Singh^3BC, Zoltan Laszik^4BC, Deborah B. Adey^1CDE, Raja Rajalingam

^2ADEF*

DOI: 10.12659/AOT.934175

Ann Transplant 2021; 26:e934175

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Figure 1 Solid-phase complement-binding characteristics of de novo donor-specific HLA antibodies (dnDSA) in kidney transplant recipientsRelationship between median fluorescence intensity (MFI) of de novo IgG DSA and ability of C1q or C3d-binding capacity. For recipients with multiple dnDSAs, only the immunodominant dnDSAs defined by the highest MFI are plotted. Some of the C3d+ DSA can be also positive for C1q, and vice versa.

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Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d⁺ Antibody-Mediated Rejection in Kidney Transplant Recipients

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