Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

01 December 2021: Original Paper

Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d Antibody-Mediated Rejection in Kidney Transplant Recipients

Vasishta S. Tatapudi 1*BDEF# , Dessislava Kopchaliiska 2ABC* , Gilberto J. da Gente 2C , Owen F. Buenaventura 2BC , Manpreet Singh 1BC$ , Zoltan Laszik 3BC , Deborah B. Adey 1CDE , Raja Rajalingam 2ADEF*

DOI: 10.12659/AOT.934175

Ann Transplant 2021; 26:e934175

Figure 2 Nature of de novo donor-specific HLA antibodies (dnDSA) in kidney transplant recipientsMost de novo DSA in kidney transplant recipients are HLA class II antigen-specific. Shown is the relationship between median fluorescence intensity (MFI) of de novo class I and class II IgG DSA and ability of C1q or C3d-binding capacity. For recipients with multiple dnDSAs, only the immunodominant dnDSAs defined by the highest IgG MFI are plotted. Some of the C3d+ DSA can be also positive for C1q, and vice versa.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358