01 December 2021 : Original article
Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d⁺ Antibody-Mediated Rejection in Kidney Transplant Recipients
Vasishta S. Tatapudi1BDEF, Dessislava Kopchaliiska2ABC, Gilberto J. da Gente2C, Owen F. Buenaventura2BC, Manpreet Singh3BC, Zoltan Laszik4BC, Deborah B. Adey1CDE, Raja Rajalingam
2ADEF*
DOI: 10.12659/AOT.934175
Ann Transplant 2021; 26:e934175
Figure 2 Nature of de novo donor-specific HLA antibodies (dnDSA) in kidney transplant recipientsMost de novo DSA in kidney transplant recipients are HLA class II antigen-specific. Shown is the relationship between median fluorescence intensity (MFI) of de novo class I and class II IgG DSA and ability of C1q or C3d-binding capacity. For recipients with multiple dnDSAs, only the immunodominant dnDSAs defined by the highest IgG MFI are plotted. Some of the C3d+ DSA can be also positive for C1q, and vice versa.