01 December 2021>: Original Paper
Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d Antibody-Mediated Rejection in Kidney Transplant RecipientsVasishta S. Tatapudi 1*BDEF# , Dessislava Kopchaliiska 2ABC* , Gilberto J. da Gente 2C , Owen F. Buenaventura 2BC , Manpreet Singh 1BC$ , Zoltan Laszik 3BC , Deborah B. Adey 1CDE , Raja Rajalingam 2ADEF*
Ann Transplant 2021; 26:e934175
Figure 2 Nature of de novo donor-specific HLA antibodies (dnDSA) in kidney transplant recipientsMost de novo DSA in kidney transplant recipients are HLA class II antigen-specific. Shown is the relationship between median fluorescence intensity (MFI) of de novo class I and class II IgG DSA and ability of C1q or C3d-binding capacity. For recipients with multiple dnDSAs, only the immunodominant dnDSAs defined by the highest IgG MFI are plotted. Some of the C3d+ DSA can be also positive for C1q, and vice versa.