Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d⁺ Antibody-Mediated Rejection in Kidney Transplant Recipients

Vasishta S. Tatapudi; Dessislava Kopchaliiska; Gilberto J. da Gente; Owen F. Buenaventura; Manpreet Singh; Zoltan Laszik; Deborah B. Adey; Raja Rajalingam

doi:10.12659/AOT.934175

01 December 2021: Original Paper

Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d Antibody-Mediated Rejection in Kidney Transplant Recipients

Vasishta S. Tatapudi ^1*BDEF# , Dessislava Kopchaliiska ^2ABC* , Gilberto J. da Gente ^2C , Owen F. Buenaventura ^2BC , Manpreet Singh ^1BC$ , Zoltan Laszik ^3BC , Deborah B. Adey ^1CDE , Raja Rajalingam ^2ADEF*

DOI: 10.12659/AOT.934175

Ann Transplant 2021; 26:e934175

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Figure 3 Nature of de novo donor-specific HLA class II antibodies in kidney transplant recipientsMost de novo DSA in kidney transplant recipients are HLA-DQ antigen-specific. Shown is the relationship between median fluorescence intensity (MFI) of de novo class II IgG DSA and the ability of C1q or C3d-binding capacity.

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Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d Antibody-Mediated Rejection in Kidney Transplant Recipients

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