05 July 2022>: Original Paper
Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation
Silvio H. Litovsky 1BDE , Jeremy B. Foote 2BCDE , Abhijit Jagdale 3BE , Gregory Walcott 4BE , Hayato Iwase 3BDE , Mohamed H. Bikhet 3BDE , Takayuki Yamamoto 3BE , Christophe Hansen-Estruch 3BE , Mohamed B. Ezzelarab 5BE , David Ayares 6AE , Waldemar F. Carlo 7BE , Leslie A. Rhodes 7BE , Jack H. Crawford 8BE , Santiago Borasino 8BE , Robert J. Dabal 8BE , Luz A. Padilla 8BE , Hidetaka Hara 3BE , David K.C. Cooper 3ABDEFG* , David C. Cleveland 8ABDEFGDOI: 10.12659/AOT.935338
Ann Transplant 2022; 27:e935338
Figure 2 Histopathology of the pig heart (A, B) and baboon lungs (C, D) in B217 at necropsy(A, B) The heart showed multifocal foci of hemorrhage and myocardial necrosis, particularly within the left ventricle, suggestive of ischemia-reperfusion injury. (C, D) The lungs exhibited minimal lesions in airways and alveoli, but showed clusters of neutrophils in small vessels, and pulmonary edema (not shown).