Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation

Silvio H. Litovsky; Jeremy B. Foote; Abhijit Jagdale; Gregory Walcott; Hayato Iwase; Mohamed H. Bikhet; Takayuki Yamamoto; Christophe Hansen-Estruch; Mohamed B. Ezzelarab; David Ayares; Waldemar F. Carlo; Leslie A. Rhodes; Jack H. Crawford; Santiago Borasino; Robert J. Dabal; Luz A. Padilla; Hidetaka Hara; David K.C. Cooper; David C. Cleveland

doi:10.12659/AOT.935338

05 July 2022 : Original article

Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation

Silvio H. Litovsky^1BDE, Jeremy B. Foote^2BCDE, Abhijit Jagdale^3BE, Gregory Walcott^4BE, Hayato Iwase^3BDE, Mohamed H. Bikhet^3BDE, Takayuki Yamamoto^3BE, Christophe Hansen-Estruch^3BE, Mohamed B. Ezzelarab^5BE, David Ayares^6AE, Waldemar F. Carlo^7BE, Leslie A. Rhodes^7BE, Jack H. Crawford^8BE, Santiago Borasino^8BE, Robert J. Dabal^8BE, Luz A. Padilla^8BE, Hidetaka Hara^3BE, David K.C. Cooper^3ABDEFG*, David C. Cleveland^8ABDEFG

DOI: 10.12659/AOT.935338

Ann Transplant 2022; 27:e935338

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Figure 2 Histopathology of the pig heart (A, B) and baboon lungs (C, D) in B217 at necropsy(A, B) The heart showed multifocal foci of hemorrhage and myocardial necrosis, particularly within the left ventricle, suggestive of ischemia-reperfusion injury. (C, D) The lungs exhibited minimal lesions in airways and alveoli, but showed clusters of neutrophils in small vessels, and pulmonary edema (not shown).

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Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation

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