05 July 2022: Original Paper
Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation
Silvio H. Litovsky 1BDE , Jeremy B. Foote 2BCDE , Abhijit Jagdale 3BE , Gregory Walcott 4BE , Hayato Iwase 3BDE , Mohamed H. Bikhet 3BDE , Takayuki Yamamoto 3BE , Christophe Hansen-Estruch 3BE , Mohamed B. Ezzelarab 5BE , David Ayares 6AE , Waldemar F. Carlo 7BE , Leslie A. Rhodes 7BE , Jack H. Crawford 8BE , Santiago Borasino 8BE , Robert J. Dabal 8BE , Luz A. Padilla 8BE , Hidetaka Hara 3BE , David K.C. Cooper 3ABDEFG* , David C. Cleveland 8ABDEFGDOI: 10.12659/AOT.935338
Ann Transplant 2022; 27:e935338
Figure 4 Histopathology of the pig heart (A–D) in B15416 at necropsy(A) The heart showed mild inflammation and fibrosis within the myocardial interstitium, and around the Purkinje fibers. Higher magnification showed a fair number of eosinophils in the infiltrate (B). The coronary arteries (C) exhibited significant mature fibrin thrombi, resulting in narrow intravascular lumens. Within the lungs (and heart, not shown), there were multiple medium-caliber arteries with endothelial activation (D, arrow).