Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation

Silvio H. Litovsky; Jeremy B. Foote; Abhijit Jagdale; Gregory Walcott; Hayato Iwase; Mohamed H. Bikhet; Takayuki Yamamoto; Christophe Hansen-Estruch; Mohamed B. Ezzelarab; David Ayares; Waldemar F. Carlo; Leslie A. Rhodes; Jack H. Crawford; Santiago Borasino; Robert J. Dabal; Luz A. Padilla; Hidetaka Hara; David K.C. Cooper; David C. Cleveland

doi:10.12659/AOT.935338

05 July 2022 : Original article

Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation

Silvio H. Litovsky^1BDE, Jeremy B. Foote^2BCDE, Abhijit Jagdale^3BE, Gregory Walcott^4BE, Hayato Iwase^3BDE, Mohamed H. Bikhet^3BDE, Takayuki Yamamoto^3BE, Christophe Hansen-Estruch^3BE, Mohamed B. Ezzelarab^5BE, David Ayares^6AE, Waldemar F. Carlo^7BE, Leslie A. Rhodes^7BE, Jack H. Crawford^8BE, Santiago Borasino^8BE, Robert J. Dabal^8BE, Luz A. Padilla^8BE, Hidetaka Hara^3BE, David K.C. Cooper^3ABDEFG*, David C. Cleveland^8ABDEFG

DOI: 10.12659/AOT.935338

Ann Transplant 2022; 27:e935338

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Figure 4 Histopathology of the pig heart (A–D) in B15416 at necropsy(A) The heart showed mild inflammation and fibrosis within the myocardial interstitium, and around the Purkinje fibers. Higher magnification showed a fair number of eosinophils in the infiltrate (B). The coronary arteries (C) exhibited significant mature fibrin thrombi, resulting in narrow intravascular lumens. Within the lungs (and heart, not shown), there were multiple medium-caliber arteries with endothelial activation (D, arrow).

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Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation

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