05 July 2022>: Original Paper
Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation
Silvio H. Litovsky 1BDE , Jeremy B. Foote 2BCDE , Abhijit Jagdale 3BE , Gregory Walcott 4BE , Hayato Iwase 3BDE , Mohamed H. Bikhet 3BDE , Takayuki Yamamoto 3BE , Christophe Hansen-Estruch 3BE , Mohamed B. Ezzelarab 5BE , David Ayares 6AE , Waldemar F. Carlo 7BE , Leslie A. Rhodes 7BE , Jack H. Crawford 8BE , Santiago Borasino 8BE , Robert J. Dabal 8BE , Luz A. Padilla 8BE , Hidetaka Hara 3BE , David K.C. Cooper 3ABDEFG* , David C. Cleveland 8ABDEFGDOI: 10.12659/AOT.935338
Ann Transplant 2022; 27:e935338
Figure 5 Histopathology of the pig heart (A–D) in B1917 at necropsy(A) Coronary artery with layers of intimal hyperplasia, suggesting prior episodes of luminal thrombosis followed by organization. (B) Veins showed subendothelial (and perivascular) inflammation that contained a mixed inflammatory infiltrate that included eosinophils (arrow). (C) The myocardial interstitium showed areas of mixed inflammation including eosinophils (arrows). (D) The myocardial interstitium showed evidence of remote scarring (dark blue; white arrow) and more recent scarring (light blue; black arrow) [trichrome stain].