Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation

Silvio H. Litovsky; Jeremy B. Foote; Abhijit Jagdale; Gregory Walcott; Hayato Iwase; Mohamed H. Bikhet; Takayuki Yamamoto; Christophe Hansen-Estruch; Mohamed B. Ezzelarab; David Ayares; Waldemar F. Carlo; Leslie A. Rhodes; Jack H. Crawford; Santiago Borasino; Robert J. Dabal; Luz A. Padilla; Hidetaka Hara; David K.C. Cooper; David C. Cleveland

doi:10.12659/AOT.935338

05 July 2022 : Original article

Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation

Silvio H. Litovsky^1BDE, Jeremy B. Foote^2BCDE, Abhijit Jagdale^3BE, Gregory Walcott^4BE, Hayato Iwase^3BDE, Mohamed H. Bikhet^3BDE, Takayuki Yamamoto^3BE, Christophe Hansen-Estruch^3BE, Mohamed B. Ezzelarab^5BE, David Ayares^6AE, Waldemar F. Carlo^7BE, Leslie A. Rhodes^7BE, Jack H. Crawford^8BE, Santiago Borasino^8BE, Robert J. Dabal^8BE, Luz A. Padilla^8BE, Hidetaka Hara^3BE, David K.C. Cooper^3ABDEFG*, David C. Cleveland^8ABDEFG

DOI: 10.12659/AOT.935338

Ann Transplant 2022; 27:e935338

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Figure 6 Immunohistochemistry of heart in B1917 was consistent with acute antibody-mediated and chronic cell-mediated rejectionLeft ventricle with significant IgM (A) and C4d (B) staining of interstitial capillary endothelium is consistent with antibody-mediated rejection. Interventricular septum displays significant numbers of CD3+ T cells (C) and IgM+ B cells (D) that is consistent with cell-mediated rejection

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Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation

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