Cyclosporine A Does Not Mitigate Liver Ischemia/Reperfusion Injury in an Ex Vivo Porcine Model of Donation After Circulatory Death

Joshua Hefler; Sanaz Hatami; Aducio Thiesen; Mitchell J. Wagner; Guilherme Mainardi; Sayed Himmat; Constantine J. Karvellas; David L. Bigam; Darren H. Freed; A.M. James Shapiro

doi:10.12659/AOT.941054

30 January 2024 : Original article

Cyclosporine A Does Not Mitigate Liver Ischemia/Reperfusion Injury in an Ex Vivo Porcine Model of Donation After Circulatory Death

Joshua Hefler

^1ABCDEF, Sanaz Hatami

^23ABCDE, Aducio Thiesen

^4DE, Mitchell J. Wagner^1BE, Guilherme Mainardi

^1BE, Sayed Himmat

^1BE, Constantine J. Karvellas

^2AE, David L. Bigam

^1AE, Darren H. Freed

^13AEG, A.M. James Shapiro

^135ADEG*

DOI: 10.12659/AOT.941054

Ann Transplant 2024; 29:e941054

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Figure 4 Cumulative (A) and total (B) bile output over 12 hours reperfusion for control (Ctrl) and treated (CsA) livers subject to 45 or 60 minutes of warm ischemia (45 m WIT, 60 m WIT) and 2 or 4 hours of cold ischemia (2 h CIT, 4 h CIT). Created in Prism (v9.0, GraphPad Software, Inc.).

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Cyclosporine A Does Not Mitigate Liver Ischemia/Reperfusion Injury in an Ex Vivo Porcine Model of Donation After Circulatory Death

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