Cyclosporine A Does Not Mitigate Liver Ischemia/Reperfusion Injury in an Ex Vivo Porcine Model of Donation After Circulatory Death

Joshua Hefler; Sanaz Hatami; Aducio Thiesen; Mitchell J. Wagner; Guilherme Mainardi; Sayed Himmat; Constantine J. Karvellas; David L. Bigam; Darren H. Freed; A.M. James Shapiro

doi:10.12659/AOT.941054

30 January 2024 : Original article

Cyclosporine A Does Not Mitigate Liver Ischemia/Reperfusion Injury in an Ex Vivo Porcine Model of Donation After Circulatory Death

Joshua Hefler

^1ABCDEF, Sanaz Hatami

^23ABCDE, Aducio Thiesen

^4DE, Mitchell J. Wagner^1BE, Guilherme Mainardi

^1BE, Sayed Himmat

^1BE, Constantine J. Karvellas

^2AE, David L. Bigam

^1AE, Darren H. Freed

^13AEG, A.M. James Shapiro

^135ADEG*

DOI: 10.12659/AOT.941054

Ann Transplant 2024; 29:e941054

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Figure 8 Oxygen (O2) consumption over the over the course of reperfusion (A) and at peak levels (B) for control (Ctrl) and treated (CsA) livers subject to 45 or 60 minutes of warm ischemia (45 m WIT, 60 m WIT) and 2 or 4 hours of cold ischemia (2 h CIT, 4 Hh CIT). Created in Prism (v9.0, GraphPad Software, Inc.).

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Cyclosporine A Does Not Mitigate Liver Ischemia/Reperfusion Injury in an Ex Vivo Porcine Model of Donation After Circulatory Death

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