Cyclosporine A Does Not Mitigate Liver Ischemia/Reperfusion Injury in an Ex Vivo Porcine Model of Donation After Circulatory Death

Joshua Hefler; Sanaz Hatami; Aducio Thiesen; Mitchell J. Wagner; Guilherme Mainardi; Sayed Himmat; Constantine J. Karvellas; David L. Bigam; Darren H. Freed; A.M. James Shapiro

doi:10.12659/AOT.941054

30 January 2024: Original Paper

Cyclosporine A Does Not Mitigate Liver Ischemia/Reperfusion Injury in an Ex Vivo Porcine Model of Donation After Circulatory Death

Joshua Hefler ^1ABCDEF , Sanaz Hatami ^23ABCDE , Aducio Thiesen ^4DE , Mitchell J. Wagner ^1BE , Guilherme Mainardi ^1BE , Sayed Himmat ^1BE , Constantine J. Karvellas ^2AE , David L. Bigam ^1AE , Darren H. Freed ^13AEG , A.M. James Shapiro ^135ADEG*

DOI: 10.12659/AOT.941054

Ann Transplant 2024; 29:e941054

Authors information Article notes Copyright and License information

Background Material and Methods Results Discussion Conclusions References

View HTML version

Figure 8 Oxygen (O2) consumption over the over the course of reperfusion (A) and at peak levels (B) for control (Ctrl) and treated (CsA) livers subject to 45 or 60 minutes of warm ischemia (45 m WIT, 60 m WIT) and 2 or 4 hours of cold ischemia (2 h CIT, 4 Hh CIT). Created in Prism (v9.0, GraphPad Software, Inc.).

Back to the Article

Cyclosporine A Does Not Mitigate Liver Ischemia/Reperfusion Injury in an Ex Vivo Porcine Model of Donation After Circulatory Death

Your Privacy