30 January 2024 : Original article
Cyclosporine A Does Not Mitigate Liver Ischemia/Reperfusion Injury in an Ex Vivo Porcine Model of Donation After Circulatory Death
Joshua Hefler
1ABCDEF, Sanaz Hatami 23ABCDE, Aducio Thiesen 4DE, Mitchell J. Wagner1BE, Guilherme Mainardi 1BE, Sayed Himmat 1BE, Constantine J. Karvellas 2AE, David L. Bigam 1AE, Darren H. Freed 13AEG, A.M. James Shapiro 135ADEG*
DOI: 10.12659/AOT.941054
Ann Transplant 2024; 29:e941054
Figure 9 Histological injury scores for biopsies taken at 2 (T2), 6 (T6), and 12 (T12) hours (A) for control (Ctrl) and treated (CsA) livers subject to 45 or 60 minutes of warm ischemia (45 m WIT, 60 m WIT) and 2 or 4 hours of cold ischemia (2 h CIT, 4 h CIT). Representative images of minimal, moderate, and severe injury taken at 50× magnification (B). Created in Prism (v9.0, GraphPad Software, Inc.).