The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice

Mark D. Minden; Cindy Audiger; Geneviève Chabot-Roy; Sylvie Lesage; Jean-Sébastien Delisle; Barbara Biemans; Violetta Dimitriadou

doi:10.12659/AOT.945249

05 November 2024 : Original article

The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice

Mark D. Minden^1ABCDE, Cindy Audiger^23BCDE, Geneviève Chabot-Roy^2BCDE, Sylvie Lesage

^23ABCDE, Jean-Sébastien Delisle

^24BCDE, Barbara Biemans^5ADE, Violetta Dimitriadou^5ABCDE*

DOI: 10.12659/AOT.945249

Ann Transplant 2024; 29:e945249

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Figure 11 Effect of apraglutide on colon length following TBI and allogeneic transplantation. Data are shown as mean±SEM values for length of intestinal colon. n=5–10 per group. Each dot represents data for one mouse. Data show that the length of the colon of TBI/BMT animals was significantly shorter as compared with the vehicle group or the TBI/BMT group treated with apraglutide (Brown-Forsythe and Welch ANOVA tests). No difference was observed between the vehicle group and the TBI/BMT animals treated with apraglutide. TBI at 7.0 Gy was applied. * P<0.01. ANOVA – analysis of variance; SEM4– standard error of mean; TBI – total body irradiation.

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The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice

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