The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice

Mark D. Minden; Cindy Audiger; Geneviève Chabot-Roy; Sylvie Lesage; Jean-Sébastien Delisle; Barbara Biemans; Violetta Dimitriadou

doi:10.12659/AOT.945249

05 November 2024 : Original article

The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice

Mark D. Minden^1ABCDE, Cindy Audiger^23BCDE, Geneviève Chabot-Roy^2BCDE, Sylvie Lesage

^23ABCDE, Jean-Sébastien Delisle

^24BCDE, Barbara Biemans^5ADE, Violetta Dimitriadou^5ABCDE*

DOI: 10.12659/AOT.945249

Ann Transplant 2024; 29:e945249

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Figure 5 Dose-dependent effect of apraglutide on serum citrulline concentration following treatment with cytarabine. Data are shown as treatment group mean±SEM values. n=3 per treatment group; citrulline levels were only determined in specifically designated animals. * Significant difference relative to vehicle-only control animals. # Significant difference relative to the cytarabine/vehicle-treated animals, as determined by one-way ANOVA and Newman-Keuls multiple comparison post hoc analysis. BID – twice daily; SEM – standard error of mean.

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The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice

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