The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice

Mark D. Minden; Cindy Audiger; Geneviève Chabot-Roy; Sylvie Lesage; Jean-Sébastien Delisle; Barbara Biemans; Violetta Dimitriadou

doi:10.12659/AOT.945249

05 November 2024 : Original article

The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice

Mark D. Minden^1ABCDE, Cindy Audiger^23BCDE, Geneviève Chabot-Roy^2BCDE, Sylvie Lesage

^23ABCDE, Jean-Sébastien Delisle

^24BCDE, Barbara Biemans^5ADE, Violetta Dimitriadou^5ABCDE*

DOI: 10.12659/AOT.945249

Ann Transplant 2024; 29:e945249

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Figure 8 Apraglutide improves gastrointestinal pathological score following induction of aGvHD (TBI 7 Gy). Group A: TBI/transplanted mice treated with apraglutide; Group B: TBI/transplanted mice treated with vehicle; Group C: control mice treated with vehicle only and no transplantation. GvHD – graft-versus-host disease; TBI – total body radiation.

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The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice

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