23 October 2020 : Original article
Transplant Radical Nephrectomy and Transplant Radical Nephroureterectomy for Renal Cancer: Postoperative and Survival Outcomes
Reza Nabavizadeh1ABCDEF*, Anika A. Noorali2ABCDEF, Salima S. Makhani2ABCDEF, Gordon Hong3ABC, Sarah Holzman4CDE, Dattatraya H. Patil1CDE, Frances Y. Kim1BCF, Paul L. Tso5ADE, Nicole A. Turgeon6DEF, Kenneth Ogan17ADEF, Viraj A. Master17ADEFDOI: 10.12659/AOT.925865
Ann Transplant 2020; 25:e925865
Table 6 Literature review of renal allograft UCC treated by transplant radical nephroureterectomy.
| First Author | No. of transplant recipients | No. with allograft cancer (n, %) | No. with UCC (n, %) | TRNU (n) | Age at tumor diagnosis; sex | Primary kidney disease (n) |
|---|---|---|---|---|---|---|
| Leon []* | 56,806 | 107 (0.18%) | 11 (0.02%) | TRNU (11) | 56.7 (mean); N/A | Glomerulonephritis (4), PCKD (2), uropathy (1), renal cancer (1), arterial hypertension (1), immune disease (1); unknown (1) |
| Saleeb []9 | 1,584 | 4 (0.25%) | 1 (0.06%) | “Resection of the allograft kidney for tumor” (1) | 66; F | Unknown |
| Leon []* | 5.6 (1.2–8.1, range) | Gross hematuria (4), Systematic urine cytology (1), Follow-up US (3), Follow-up CT (2) and MRI due to arterial hypertension (1) | Papillary UCC (11), High-grade (10), Low-grade (1) | 60 mo (mean) (13.5–87.5);alive (10);deceased (1) (UTUC) | ||
| Saleeb []9 | 9 | N/A | Papillary UCC, High-grade | 24 mo, alive, no recurrence | ||
| Farkas []10 | N/A | 1 | 1 | “Graft was surgically removed” (1) | 63; M | IgA nephropathy |
| Hong []36 | N/A | 1 | 1 | TRNU (1) | 40; M | Unknown |
| Farkas []10 | 9 | Painless, gross hematuria and asymptomatic hydronephrosis | UCC, High-grade | 21 mo, alive, no recurrence | ||
| Hong []36 | 10 | Gross hematuria and GI symptoms | UCC, Low-grade | 24 mo, alive, no recurrence | ||
| UCC – urothelial cell carcinoma; TRNU – transplant radical nephroureterectomy; mo – months; N/A – not available; UTUC – upper tract urothelial cancer; RCC – renal cell carcinoma; US – ultrasound; CT – computerized tomography; MRI – magnetic resonance imaging; Cr – creatinine; IN – interstitial nephropathy; IgA – immunoglobulin-A; PCKD – polycystic kidney disease; Gastrointestinal (GI) symptoms: Abdominal pain, nausea, vomiting, diarrhea. * National, multicenter study. | ||||||