20 October 2020: Review Paper
Clinical Relevance of Kidney Biopsy in Patients Qualified for Liver Transplantation and After This Procedure in the Model for End-stage Liver Disease (MELD) Era: Where Are We Today?
Monika Wieliczko ABCDEF , Urszula Ołdakowska-Jedynak BCEF , Jolanta Małyszko ABCDEFG*DOI: 10.12659/AOT.925891
Ann Transplant 2020; 25:e925891
Table 3 Transjugular kidney biopsy in liver transplant recipients.
| First author/reference number/study period | Number of patients | The most common causes of ESLD | Renal biopsy indication | Renal biopsy results | Clinical implication |
|---|---|---|---|---|---|
| Jouet et al. [] 19961987–199422 | 55 | ALD | Patients considered for LTx | Glomerular lesions Interstitial abnormalitiesEnd-stage kidneyNormal histology | The transjugular biopsy may be a useful procedure in patients with cirrhosis and clotting disorders. This approach may influence treatment decisions in patients proposed for liver transplantation. |
| Sam et al. [] 200123 | 29 | No data | Tubular injury MPGNNephrosclerosisMinimal change diseaseESRDGSNonspecific changesNo abnormality in 4 cases | Irrespective of urine or blood findings, glomerular, and tubular abnormalities are relatively common in the setting of advanced liver disease. | |
| Abbott et al. [] 20021996–200130 | 9 | No data | – | Transjugular biopsy appears to be efficacious in high-risk patients for whom percutaneous procedure is contraindicated. | |
| AKI – acute kidney injury; ATN – acute tubular necrosis; CKD – chronic kidney disease; CNI – calcineurin inhibitor; CsA – cyclosporine A; DM – diabetes mellitus; DN – diabetic nephropathy; ESLD – end-stage liver disease; FSGS – focal segmental glomerulosclerosis; GN – glomerulonephritis; GS – glomerulosclerosis; HGS – hepatic glomerulosclerosis; HP – hypertension IF interstitial fibrosis; IgA – immunoglobulin A; HBV – hepatitis B virus; HCV – hepatitis C virus; ALD – alcoholic liver disease; IFTA – interstitial fibrosis and tubular atrophy; LAT – alone liver transplantation; LTx – liver transplantation; MGA – minor glomerular abnormalities; MPGN – membranoproliferative glomerulonephritis; NA – not available; NASH – nonalcoholic steatohepatitis; NRSOT – nonrenal solid organ transplantation; RB – renal biopsy; RRT – renal replacement therapy; SLK – tx simultaneous-liver-kidney transplantation; TA – tubular atrophy; TAC – tacrolimus; TMA – thrombotic microangiopathy; TDV – tenofovir-associated nephrotoxicity. | |||||