04 December 2020 : Clinical Research
Predictors of Mortality During Initial Liver Transplant Hospitalization and Investigation of Causes of Death
Ni Gong1BE, Chao Jia2CDF, He Huang3CEF, Jing Liu4BCD, XueTing Huang4CF, Qiquan Wan4ADG*DOI: 10.12659/AOT.926020
Ann Transplant 2020; 25:e926020
Table 1 The characteristics of DCD donors and LT recipients (N=103).
| Characteristics | Value |
|---|---|
| Donor age, mean yrs±SD | 40.5±14.0 |
| Donor gender, no. of male (%) | 89 (86.4%) |
| Cold ischemia time, mean hrs±SD | 5.6±1.8 |
| Recipient age, mean yrs±SD | 47.7±10.0 |
| Recipient gender, no. of male (%) | 86 (83.5) |
| Etiology of liver disease, n(%) | |
| Noncholestatic cirrhosis | 38 (36.9) |
| Hepatitis B | 28 (27.2) |
| Alcoholic | 7 (6.8) |
| Hepatic venule occlusion syndrome | 2 (2.0) |
| Autoimmune | 1 (1.0) |
| Hepatic cirrhosis plus necrosis | 29 (28.2) |
| Acute hepatic necrosis | 22 (21.4) |
| Liver cirrhosis plus carcinoma | 9 (8.7) |
| Cholestatic liver disease | 3 (2.9) |
| Biliary atresia | 1 (1.0) |
| Other | 1 (1.0) |
| Pretransplant diabetes, n (%) | 8 (7.8) |
| Median MELD score at LT (IQR) | 32.4 (21.4–38.4) |
| MELD score greater than 30, n (%) | 61 (59.2) |
| Infections before LT, n(%) | 49 (47.6) |
| Hospital stay prior to LT, mean days±SD | 7.2±10.6 |
| Median duration of hrs of operation (IQR) | 6.3 (5.7–7.0) |
| Red blood cell infusions, mean units±SD | 16.3±7.2 |
| Induction therapy, n (%) | |
| Use of basiliximab | 10 (9.7) |
| Use of rituximab | 1 (1.0) |
| Immunosuppressant treatment, n (%) | |
| Tacrolimus | 97 (94.2) |
| Cyclosporine A | 3 (2.9) |
| Without any calcineurin inhibitor | 3 (2.9) |
| Reoperation, n (%) | 4 (3.9) |
| Postoperative bacteremias, n (%) | 5 (4.9) |
| Postoperative pneumonia, n (%) | 41 (39.8) |
| Postoperative bleeding | 4 (3.9) |
| Gastrointestinal | 3 (2.9) |
| Respiratory | 1 (1.0) |
| Acute rejection, n (%) | 8 (7.8) |
| Creatinine on day 3 after LT, mean mg/dL±SD | 1.2±1.0 |
| ALT on day 1 after LT, mean μmol/L±SD | 1003.7±1051.7 |
| ICU stay, mean days±SD | 6.6±4.4 |
| Whole hospitalized days, mean days±SD | 33.9±13.9 |
| Median days between death and LT (IQR) | 16 (14–27) |
| Causes of in-hospital mortality, n(%) | |
| Bacteremia | 3 (2.9) |
| Bacteremia plus ARDS due to pneumonia | 1 (1.0) |
| ARDS due to pneumonia | 1 (1.0) |
| Intra-abdominal infection | 1 (1.0) |
| Primary graft failure | 1 (1.0) |
| ALT – alanine transaminase; ARDS – acute respiratory distress syndrome; DCD – donation after citizen’s death; ICU – Intensive Care Unit; IQR – interquartile range; LT – liver transplantation; SD – standard deviation. | |