04 December 2020 : Clinical Research
Predictors of Mortality During Initial Liver Transplant Hospitalization and Investigation of Causes of Death
Ni Gong1BE, Chao Jia2CDF, He Huang3CEF, Jing Liu4BCD, XueTing Huang4CF, Qiquan Wan4ADG*DOI: 10.12659/AOT.926020
Ann Transplant 2020; 25:e926020
Table 2 Univariate analysis of risk factors associated with mortality during initial LT hospitalization.
| Characteristics | Survival group | Death group | P |
|---|---|---|---|
| Total, n (%) | 96 (93.2) | 7 (6.8) | |
| Univariate analysis | |||
| Donor age (yrs) | 40.1±14.2 | 45.9±8.9 | 0.288 |
| Donor Male gender, n (%) | 82 (85.4) | 7 (100.0) | 0.277 |
| Cold ischemia time, mean hrs±SD | 5.4±1.4 | 5.8±1.3 | 0.721 |
| Recipient age, mean yrs±SD | 47.6±9.8 | 50.0±13.1 | 0.529 |
| Recipient male gender, n (%) | 81 (84.4) | 5 (71.4) | 0.373 |
| Acute hepatic necrosis, n (%) | 17 (17.7) | 5 (71.4) | <0.01* |
| Pretransplant diabetes, n (%) | 8 (8.3) | 0 (0) | 0.426 |
| Median MELD score at LT (IQR) | 31.4 (21.4–38.2) | 40.0 (20.4–40.0) | 0.370 |
| Pretransplant infections, n (%) | 45 (46.9) | 4 (57.1) | 0.599 |
| Hospital stay prior to LT, mean days±SD | 7.2±10.8 | 6.6±8.3 | 0.872 |
| Median duration of hrs of operation (IQR) | 6.3 (5.7–7.0) | 6.6 (5.6–6.8) | 0.768 |
| Red blood cell infusions, mean units±SD | 16.1±7.2 | 18.7±7.7 | 0.350 |
| Induction therapy, n (%) | 10 (10.4) | 1 (14.3) | 0.749 |
| The use of Tacrolimus, n (%) | 93 (96.9) | 4 (57.1) | <0.001* |
| Reoperation, n(%) | 4 (4.2) | 0 (0) | 0.582 |
| Postoperative bacteremia, n (%) | 1 (1.0) | 4 (57.1) | <0.001** |
| Postoperative pneumonia, n (%) | 35 (36.5) | 6 (85.7) | <0.05* |
| Acute rejection, n(%) | 8 (8.3) | 0 (0) | 0.426 |
| Creatinine on day 3 post-LT >2 mg/dL, n (%) | 7 (7.3) | 4 (57.1) | <0.001 |
| ALT on day 1 post-LT >1800 μmol/L | 10 (10.4) | 5 (71.4) | <0.001* |
| ICU stay ≥7 days, n (%) | 24 (25.0) | 6 (85.7) | <0.01* |
| Whole hospital stay, mean days±SD | 34.5±13.3 | 26.4±20.3 | 0.138 |
| CI – confidence interval; ICU – Intensive Care Unit; IQR – interquartile range; LT – liver transplantation; MELD – model for end stage liver disease; SD – standard deviation. * χ test; ** Fisher’s exact test. | |||