03 November 2020 : Original article
Comorbidity Burden May Be Associated with Increased Mortality in Patients with Severe Acute Liver Injury Referred for Liver Transplantation
Lindsey Steiner-Temnykh1ABCDEF, Lara Dakhoul2ABCDEF, James Slaven3ACDE, Lauren Nephew2BCDEF, Kavish R. Patidar2BCDEF, Eric Orman2BCDEF, Archita P. Desai2BCDEF, Eduardo Vilar-Gomez2BCDEF, Chandrashekhar Kubal4BCDEF, Burcin Ekser4BCDEF, Naga Chalasani2ABCDEF, Marwan Ghabril2ABCDEF*DOI: 10.12659/AOT.926453
Ann Transplant 2020; 25:e926453
Table 5 The logistic regression analysis of predictors of 30-day mortality or liver transplantation in patients with severe acute liver injury referred for liver transplantation.
| Variable | Simple logistic regression | Multiple logistic regression | ||
|---|---|---|---|---|
| Odds ratio (95% confidence interval) | P-value | Odds ratio (95% confidence interval) | P-value | |
| CCI | 1.18 (0.96–1.46) | 0.1 | 1.17 (0.9–1.5)* | 0.3 |
| Underlying liver disease | 1.5 (0.6–4.3) | 0.4 | 0.4 (0.1–1.7)* | 0.2 |
| Age | 1.03 (0.99–1.06) | 0.07 | 0.99 (0.96–1.04)* | 0.9 |
| MELD | 1.11 (1.06–1.17) | <0.001 | 1.14 (1.07–1.2)* | <0.001 |
| Female gender | 2.1 (0.8–5.4) | 0.1 | 3 (0.8–10.4) | 0.09 |
| APAP etiology | 0.1 (0.1–0.5) | 0.001 | 0.2 (0.07–0.54) | 0.002 |
| APAP – acetaminophen; CCI – Charlson Comorbidity Index; MELD – model for endstage liver disease. * The results were similar when the multiple logistic regression was controlled for interactions of gender and APAP etiology of liver disease. | ||||