03 November 2020 : Original article
Comorbidity Burden May Be Associated with Increased Mortality in Patients with Severe Acute Liver Injury Referred for Liver Transplantation
Lindsey Steiner-Temnykh1ABCDEF, Lara Dakhoul2ABCDEF, James Slaven3ACDE, Lauren Nephew2BCDEF, Kavish R. Patidar2BCDEF, Eric Orman2BCDEF, Archita P. Desai2BCDEF, Eduardo Vilar-Gomez2BCDEF, Chandrashekhar Kubal4BCDEF, Burcin Ekser4BCDEF, Naga Chalasani2ABCDEF, Marwan Ghabril2ABCDEF*DOI: 10.12659/AOT.926453
Ann Transplant 2020; 25:e926453
Table 6 The competing risk regression analysis of predictors of mortality within 90 days, with liver transplantation as a competing risk, in patients with severe acute liver injury referred for liver transplantation.
| Variable | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| Sub-hazard ratio (95% confidence interval) | P-value | Sub-hazard ratio (95% confidence interval) | P-value | |
| CCI | 1.18 (1.03–1.35) | 0.014 | 1.17 (1.01–1.35)* | 0.037 |
| Underlying liver disease | 0.9 (0.4–2) | 0.8 | 0.4 (0.1–1.1)* | 0.07 |
| MELD | 1.05 (1.02–1.08) | <0.001 | 1.07 (1.03–1.1)* | <0.001 |
| Female gender | 2.5 (0.99–6.1) | 0.05 | 2.8 (1.04–7.7) | 0.04 |
| APAP etiology | 0.6 (0.3–1.02) | 0.06 | 0.7 (0.4–1.4) | 0.3 |
| APAP – acetaminophen; CCI – Charlson Comorbidity Index; MELD – model for endstage liver disease. * The results were similar when the multivaraible competing risk regression was controlled for interactions of gender and APAP etiology of liver disease. | ||||