03 November 2020 : Original article
Comorbidity Burden May Be Associated with Increased Mortality in Patients with Severe Acute Liver Injury Referred for Liver Transplantation
Lindsey Steiner-Temnykh1ABCDEF, Lara Dakhoul2ABCDEF, James Slaven3ACDE, Lauren Nephew2BCDEF, Kavish R. Patidar2BCDEF, Eric Orman2BCDEF, Archita P. Desai2BCDEF, Eduardo Vilar-Gomez2BCDEF, Chandrashekhar Kubal4BCDEF, Burcin Ekser4BCDEF, Naga Chalasani2ABCDEF, Marwan Ghabril2ABCDEF*DOI: 10.12659/AOT.926453
Ann Transplant 2020; 25:e926453
Supplementary Table 2 A comparison of salient demographic and clinical characteristics of patients who survived, underwent liver transplantation, or died within 90 days of presenting with severe acute liver injury. Data are shown as mean±standard deviation or number (percentage).
| Survived without LTn=71 | Underwent LTn=21 | Died without LTn=44 | P-value | |
|---|---|---|---|---|
| Age | 34±12 | 40±11 | 39±15 | 0.049 |
| Gender (Female) n (%) | 52 (73) | 15 (71) | 39 (89) | 0.11 |
| Caucasian | 57 (80) | 11 (52) | 38 (86) | 0.1 |
| Black | 9 (13) | 6 (29) | 5 (11) | |
| Acetaminophen injury | 55 (77) | 5 (24) | 20 (45) | |
| Autoimmune hepatitis | 1 (1) | 5 (24) | 4 (9) | |
| Drug-induced liver injury | 2 (3) | 3 (14) | 2 (4) | |
| Ischemic hepatitis | 5 (7) | 2 (9) | 3 (7) | |
| Viral | 2 (3) | 2 (9) | 5 (9) | |
| Undetermined | 2 (3) | 3 (14) | 8 (18) | |
| Other | 4 (6) | 1 (5) | 3 (7) | |
| Underlying liver disease n (%) | 7 (10) | 6 (29) | 5 (11) | 0.08 |
| Charlson Comorbidity Index | 0.8±1.2 | 1.2±1.9 | 1.6±2.5 | 0.07 |
| Model for End-stage Liver Disease | 26.7±9.1 | 36.9±7.8 | 35.1±9 | |
| CLIF-SOFA | 9.3±3.7 | 11.1±4.5 | 13±4 | |
| Developed ALF at any time n (%) | 50 (70) | 21 (100) | 44 (100) | |
| ALF – acute liver failure; CLIF-SOFA – Chronic Liver Failure Sequential Organ Failure Assessment. | ||||