Type 1 Diabetic Patients After Simultaneous Pancreas and Kidney Transplantation Have Less Intense Periodontal Inflammation Compared to Kidney Recipients Treated with Insulin

Mikołaj Musiał; Rafał Wiench; Aureliusz Kolonko; Piotr Choręza; Elżbieta Świętochowska; Damian Niedzielski; Agnieszka Machorowska-Pieniążęk; Dariusz Skaba; Andrzej Więcek; Aleksander J. Owczarek; Iwona Niedzielska; Robert Król; Jacek Ziaja

doi:10.12659/AOT.932426

09 November 2021 : Original article

Type 1 Diabetic Patients After Simultaneous Pancreas and Kidney Transplantation Have Less Intense Periodontal Inflammation Compared to Kidney Recipients Treated with Insulin

Mikołaj Musiał^1ABCDEF*, Rafał Wiench^2ADEF, Aureliusz Kolonko^3BD, Piotr Choręza^4CD, Elżbieta Świętochowska^5BC, Damian Niedzielski^6BF, Agnieszka Machorowska-Pieniążęk^1DG, Dariusz Skaba^2DE, Andrzej Więcek^3DE, Aleksander J. Owczarek^7CD, Iwona Niedzielska^6AD, Robert Król^8DE, Jacek Ziaja^8ADEF

DOI: 10.12659/AOT.932426

Ann Transplant 2021; 26:e932426

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Table 2 Comparison of selected parameters concerning periodontal lesions and concentration of analyzed inflammatory markers in gingival crevicular fluid between the groups of type 1 diabetic patients after simultaneous pancreas-kidney transplantation (SPK) or kidney transplantation (KTx) and control group (numbers and rates or mean±SD or median and IQR).

	SPKN=20	KTxN=16	ControlN=15	p	pSPK vs KTx	pKTx vs control	pSPK vs control

Maximal pocket depth [mm]	2.68 (2.26–3.69)	2.55 (2.14–3.39)	1.57 (1.00–1.96)	<0.001	1.00	<0.001	<0.001
Maximal clinical attachment loss [mm]	2.96 (2.30–3.84)	2.70 (1.92–4.31)	0.55 (0.15–0.81)	<0.001	0.85	<0.001	<0.001
Modified Sulcus Bleeding Index [%]	23.5 (14.0–41.5)	66.5 (29.5–89.5)	17.0 (13.0–22.0)	<0.01	0.09	<0.01	0.67
Tooth mobility [periotest value]	4.72 (2.50–9.02)	5.15 (2.72–9.21)	1.78 (1.36–2.20)	<0.01	0.99	<0.05	<0.01
Gingival crevicular fluid volume [U]	0.37±0.11	0.53±0.26	0.29±0.12	<0.01	<0.05	<0.01	0.38

IL-1 [pg/mL]	26.03±7.56	39.44±11.16	18.82±9.41	<0.001	<0.001	0.10	<0.001
MMP-8 [ng/mL]	2.48±0.80	3.85±1.16	2.00±0.89	<0.001	<0.001	0.36	<0.001
Resistin [ng/mL]	22.81±3.92	31.22±6.49	12.81±3.82	<0.001	<0.001	<0.001	<0.001
TNFα [pg/mL]	1.88 (1.65–2.09)	2.57 (2.08–3.22)	1.68 (1.49–1.94)	<0.001	<0.01	0.54	<0.001
YKL40 [pg/mL]	524.1±117.4	728.1±111.5	341.4±66.2	<0.001	<0.001	<0.001	<0.001
IL-1β – interleukin-1β; MMP-8 – matrix metalloproteinase-8; TNF-α – tumor necrosis factor-α.

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Type 1 Diabetic Patients After Simultaneous Pancreas and Kidney Transplantation Have Less Intense Periodontal Inflammation Compared to Kidney Recipients Treated with Insulin

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