Type 1 Diabetic Patients After Simultaneous Pancreas and Kidney Transplantation Have Less Intense Periodontal Inflammation Compared to Kidney Recipients Treated with Insulin

Mikołaj Musiał; Rafał Wiench; Aureliusz Kolonko; Piotr Choręza; Elżbieta Świętochowska; Damian Niedzielski; Agnieszka Machorowska-Pieniążęk; Dariusz Skaba; Andrzej Więcek; Aleksander J. Owczarek; Iwona Niedzielska; Robert Król; Jacek Ziaja

doi:10.12659/AOT.932426

09 November 2021 : Original article

Type 1 Diabetic Patients After Simultaneous Pancreas and Kidney Transplantation Have Less Intense Periodontal Inflammation Compared to Kidney Recipients Treated with Insulin

Mikołaj Musiał^1ABCDEF*, Rafał Wiench^2ADEF, Aureliusz Kolonko^3BD, Piotr Choręza^4CD, Elżbieta Świętochowska^5BC, Damian Niedzielski^6BF, Agnieszka Machorowska-Pieniążęk^1DG, Dariusz Skaba^2DE, Andrzej Więcek^3DE, Aleksander J. Owczarek^7CD, Iwona Niedzielska^6AD, Robert Król^8DE, Jacek Ziaja^8ADEF

DOI: 10.12659/AOT.932426

Ann Transplant 2021; 26:e932426

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Table 3 Univariate regression analysis between clinical and biochemical parameters, periodontal parameters, and concentration of inflammatory markers in gingival crevicular fluid in combined group of patients with ESRD in course of T1D after SPK or KTx (Pearson r or Spearman r correlation coefficients are shown).

	Creatinine (log)	Glycated hemoglobin (log)	Age at the time of study	Total diabetes duration

Max. pocket depth (log)	−0.160	0.015	−0.062	−0.106
Max. clinical attachment loss (log)	−0.133	−0.079	0.348^*	−0.155
Modified Sulcus Bleeding Index	0.135	0.439^*	0.187	−0.054
Tooth mobility (log)	0.112	0.083	0.447^*	−0.120
Gingival crevicular fluid volume	0.346^*	0.340^*	−0.001	0.020

IL-1β	0.036	0.235	−0.297	0.210
MMP-8	0.147	0.245	−0.029	0.288
Resistin	0.153	0.549^*	0.173	0.025
TNFα (log)	0.154	0.340^*	0.118	0.335^*
YKL40	0.298^*	0.475^*	0.001	0.471^*
^* IL-1β – interleukin-1β; MMP-8 – matrix metalloproteinase-8; TNF-α – tumor necrosis factor-α.

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Type 1 Diabetic Patients After Simultaneous Pancreas and Kidney Transplantation Have Less Intense Periodontal Inflammation Compared to Kidney Recipients Treated with Insulin

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