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29 October 2021: Original Paper

Impact of the Share 35 Policy on Perioperative Management and Mortality in Liver Transplantation Recipients

Warangkana Lapisatepun 12ABCDEF , Vatche G. Agopian 3BDE , Victor W. Xia 1ADEF , Worakitti Lapisatepun 34ABCDEF*

DOI: 10.12659/AOT.932895

Ann Transplant 2021; 26:e932895

Table 1 Recipient demographics, comorbidities and medical acuity of pre- and post-Share 35 transplantation.

Pre-Share 35N= 859Post-Share 35N=737P value
Age, yrs57.0 (51.0–62.0)57.0 (50.0–63.0)0.802
BMI26.9 (23.7–31.1)27.0 (23.6–31.2)0.998
Sex, Male637 (63.9%)471 (58.4%)0.043
Recipient race*
 Caucasian383 (54.8%)174 (40.8%)
 Hispanic162 (23.2%)160 (37.6%)
 Asian82 (11.7%)48 (11.3%)
 African American and other71 (10.2%)41 (10.3%)
Cause of ESLD
 Acute fulminant liver failure32 (3.8%)26 (6.4%)0.039*
 HBV60 (7.1%)23 (6.4%)0.339
 HCV260 (30.6%)113 (27.7%)0.287
 NASH, non-alcoholic steatohepatitis55 (6.5%)49 (12.0%)0.001*
 Alcohol201 (23.7%)125 (30.6%)0.008*
 Hepatocellular carcinoma414 (33.8%)190 (28.8%)0.014*
 Others69 (4.4%)16 (4.9%)0.279
Diabetics224 (27.5%)194 (29.1%)0.496
Hypertension290 (35.4%)200 (30.1%)0.031*
Coronary artery disease81 (10.0%)76 (11.4%)0.379
Preoperative factors
 Encephalopathy371 (45.6%)339 (50.8%)0.044*
 Vasopressors infusion139 (17.6%)167 (25%)0.001*
 Mechanical ventilation191 (23.5%)164 (24.5%)0.637
 Continuous renal replacement therapy (CRRT)327 (38.2%)337 (45.9%)0.002*
 Pre-transplant ICU admission23 (42.6%)312 (46.7%)0.560
 Pre-transplant cardiac arrythmia10 (18.9%)84 (12.6%)0.194
MELD score26.0 (13.0–36.0)30.0 (15.0–39.0)*
MELD score ≥35300 (34.9%)337 (45.7%)*
Waiting time in patients with MELD score ≥3518.5 (7–198.5)14.5 (5.0–66.3)0.045*
*

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358