Impact of the Share 35 Policy on Perioperative Management and Mortality in Liver Transplantation Recipients

29 October 2021 : Original article

Warangkana Lapisatepun^12ABCDEF, Vatche G. Agopian^3BDE, Victor W. Xia^1ADEF, Worakitti Lapisatepun^34ABCDEF*

DOI: 10.12659/AOT.932895

Ann Transplant 2021; 26:e932895

Table 1 Recipient demographics, comorbidities and medical acuity of pre- and post-Share 35 transplantation.

	Pre-Share 35N= 859	Post-Share 35N=737	P value
Age, yrs	57.0 (51.0–62.0)	57.0 (50.0–63.0)	0.802
BMI	26.9 (23.7–31.1)	27.0 (23.6–31.2)	0.998
Sex, Male	637 (63.9%)	471 (58.4%)	0.043
Recipient race			^*
Caucasian	383 (54.8%)	174 (40.8%)
Hispanic	162 (23.2%)	160 (37.6%)
Asian	82 (11.7%)	48 (11.3%)
African American and other	71 (10.2%)	41 (10.3%)
Cause of ESLD
Acute fulminant liver failure	32 (3.8%)	26 (6.4%)	0.039^*
HBV	60 (7.1%)	23 (6.4%)	0.339
HCV	260 (30.6%)	113 (27.7%)	0.287
NASH, non-alcoholic steatohepatitis	55 (6.5%)	49 (12.0%)	0.001^*
Alcohol	201 (23.7%)	125 (30.6%)	0.008^*
Hepatocellular carcinoma	414 (33.8%)	190 (28.8%)	0.014^*
Others	69 (4.4%)	16 (4.9%)	0.279
Diabetics	224 (27.5%)	194 (29.1%)	0.496
Hypertension	290 (35.4%)	200 (30.1%)	0.031^*
Coronary artery disease	81 (10.0%)	76 (11.4%)	0.379
Preoperative factors
Encephalopathy	371 (45.6%)	339 (50.8%)	0.044^*
Vasopressors infusion	139 (17.6%)	167 (25%)	0.001^*
Mechanical ventilation	191 (23.5%)	164 (24.5%)	0.637
Continuous renal replacement therapy (CRRT)	327 (38.2%)	337 (45.9%)	0.002^*
Pre-transplant ICU admission	23 (42.6%)	312 (46.7%)	0.560
Pre-transplant cardiac arrythmia	10 (18.9%)	84 (12.6%)	0.194
MELD score	26.0 (13.0–36.0)	30.0 (15.0–39.0)	^*
MELD score ≥35	300 (34.9%)	337 (45.7%)	^*
Waiting time in patients with MELD score ≥35	18.5 (7–198.5)	14.5 (5.0–66.3)	0.045^*
^*