15 October 2021>: Original Paper
Intraoperative Low-Dose Dexmedetomidine Administration Associated with Reduced Hepatic Ischemia-Reperfusion Injury in Pediatric Deceased Liver Transplantation: A Retrospective Cohort Study
Liang Zhang 1ABCDEF* , Na Li 1BEF* , Ling-Li Cui 1BF , Fu-Shan Xue 1ADFG* , Zhi-Jun Zhu 234ADFG*DOI: 10.12659/AOT.933354
Ann Transplant 2021; 26:e933354
Table 1 Patients’ characteristics.
Entire cohort (n=54) | Control group (n=26) | DEX group (n=28) | P value | |
---|---|---|---|---|
Age (y), median (IQR) | 3.0 (0.8–5.8) | 1.5 (0.8–5.9) | 3.5 (1.4–5.8) | 0.315 |
Female gender, n (%) | 20 (37.0) | 12 (46.2) | 8 (28.6) | 0.181 |
Height (cm), median (IQR) | 91 (68–110) | 79 (67–107) | 96 (72–110) | 0.416 |
Weight (kg), median (IQR) | 13.8 (7.4–17.6) | 10.2 (7.0–18.3) | 14.8 (7.9–17.5) | 0.416 |
Child score, median (IQR) | 7 (6–10) | 8 (6–10) | 7 (5–9) | 0.293 |
PELD score, median (IQR) | 2 (−5–15) | 8 (−3–15) | −2 (−9–17) | 0.328 |
Indication for LT, n (%) | ||||
Biliary atresia | 33 (61.1) | 17 (65.4) | 16 (57.1) | 0.535 |
UCDs | 6 (11.1) | 3 (11.5) | 3 (10.7) | 1.000 |
PFIC | 4 (7.4) | 2 (7.7) | 2 (7.1) | 1.000 |
Hepatoblastoma | 2 (3.7) | 1 (3.8) | 1 (3.6) | 1.000 |
Fulminant hepatic failure | 2 (3.7) | 1 (3.8) | 1 (3.6) | 1.000 |
Methylmalonic acidemia | 2 (3.7) | 0 (0) | 2 (7.1) | 0.491 |
Caroli disease | 2 (3.7) | 0 (0) | 2 (7.1) | 0.491 |
Wilson disease | 1 (1.9) | 1 (3.8) | 0 (0) | 0.481 |
Crigler-Najjar syndrome | 1 (1.9) | 0 (0) | 1 (3.6) | 1.000 |
Congenital hepatic fibrosis | 1 (1.9) | 1 (3.8) | 0 (0) | 0.481 |
Partial liver graft, n (%) | 12 (22.2) | 4 (15.4) | 8 (28.6) | 0.244 |
Graft weight (g), median (IQR) | 375 (300–501) | 403 (296–500) | 364 (309–506) | 0.815 |
GRWR (%), mean±SD | 3.31±1.09 | 3.46±1.10 | 3.18±1.08 | 0.346 |
CIT (min), mean±SD | 597±115 | 605±106 | 590±125 | 0.631 |
WIT (min), mean±SD | 47±12 | 52±13 | 43±10 | 0.004 |
CIT – cold ischemia time; DEX – dexmedetomidine; GRWR – graft-to-recipient weight ratio; IQR – interquartile range; PELD – Pediatric End-stage Liver Disease; PFIC – progressive familial intrahepatic cholestasis; SD – standard deviation; UCD – urea cycle disorder; WIT – warm ischemia time. |