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12 October 2021: Original Paper

Prognostic Role of Serum Albumin Level in Patients with Lymphoma Undergoing Autologous Stem Cell Transplantation

Chengxin Luo 12CDE , Qingrong Li 12B , Xi Li 3B , Guixian Wu 12B , Xiangtao Huang 12B , Yali Zhang 12B , Yanni Ma 12B , Mingling Xie 12B , Yanni Sun 12B , Yarui Huang 12B , Zhen Huang 12B , Shuangnian Xu 12AEG* , Jieping Chen 12AEG*

DOI: 10.12659/AOT.933365

Ann Transplant 2021; 26:e933365

Table 4 Results of univariate and multivariate Cox regression analyses for progression-free survival in the B-cell non-Hodgkin lymphoma subgroup.

CharacteristicsUnivariate analysisMultivariate analysis
HR (95%CI)PHR (95%CI)P
Male2.07 (0.87–4.91)0.100
Age >603.37 (1.41–8.06)0.006* 4.06 (1.67–9.86)0.002*
BMI0.04 (0.00–13.61)0.283
ECOG PS 2–31.75 (0.81–3.80)0.154
Ann Arbor stage III–IV1.47 (0.85–2.57)0.172
B symptoms0.99 (0.45–2.22)0.988
IPI risk
 Low1.00
 Low-intermediate1.46 (0.52–4.15)0.474
 High-intermediate1.68 (0.51–5.53)0.390
 High3.39 (1.13–10.18)0.029*
LDH elevation (>240 U/L)2.52 (1.18–5.40)0.017*
Bone marrow involvement3.09 (1.16–8.24)0.024*
Prior regimens
1.00
 5–101.40 (0.60–3.25)0.432
 ≥101.11 (0.53–2.35)0.783
Rituximab induction0.96 (0.44–2.09)0.909
PR or NR2.65 (1.21–5.80)0.015*
Disease duration1.00 (0.98–1.02)0.711
Albumin3.29 (1.47–7.37)0.004* 3.22 (1.42–7.29)0.005*
TP2.81 (1.26–6.27)0.012*
Globulin level0.95 (0.87–1.03)0.186
Albumin/globulin ratio0.90 (0.29–2.82)0.862
Conditioning regimen
 BEAM1.00
 BEAC1.23 (0.36–4.24)0.738
 CBV1.05 (0.32–3.50)0.935
 CHOP-like0.75 (0.20–2.80)0.667
Dose of infused mononuclear cells0.97 (0.81–1.16)0.712
Maintenance therapy1.12 (0.50–2.49)0.782
*
B-NHL – B-cell non-Hodgkin lymphoma; BEAC – carmustine, etoposide, cytarabine, and cyclophosphamide; BEAM – carmustine, etoposide, cytarabine, and melphalan; BMI – body mass index; CHOP – cyclophosphamide, anthracycline, vincristine, and prednisone; CBV – cyclophosphamide, carmustine, and etoposide; CR – complete remission; ECOG PS – Eastern Cooperative Oncology Group performance status; HL – Hodgkin lymphoma; HR – hazard ratio; IPI – international prognostic index; LDH – lactate dehydrogenase; NHL – non-Hodgkin lymphoma; NR – no response; PFS – progression-free survival; PR – partial remission; TP – total protein.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358