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29 December 2021: Meta-Analysis

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

T A Manjunatha 1ABCDEF* , Rebecca Chng 1ABCDEF , Wai-Ping Yau 2ADE

DOI: 10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

Table 1 Overview of included studies in which 1 or more of the treatment arms used Advagraf or Prograf.

StudyTAC formulationPhaseBlindingCenterRegion*Sample sizeEfficacy outcomesSafety outcomesNo. of arms
Albano 2013Advagraf, Prograf4Open-labelMulticenterInternational1251YY4
Anutrakulchai 2019PrografOpen-labelSingle-centerAsia126YN2
Arns 2017TacHexal, Prograf4Open-labelMulticenterEurope81YY2
Arriola 2018 (CA)Advagraf, Prograf107YY2
Asher 2014PrografOpen-labelSingle-centerEurope62YN2
Bakr 2018Advagraf, PrografSingle-centerAfrica99YN2
Chen 2008PrografSingle-blindAsia41YY2
Cockfield 2019AdvagrafOpen-labelMulticenterNorth America281YY2
De Graav 2017PrografOpen-labelSingle-centerEurope40YN2
Demirbas 2009Prograf4Open-labelMulticenterInternational1645YY4
Ekberg 2010 (SP to Demirbas 2009)Prograf4Open-labelMulticenterInternational1645YY4
Ferguson 2011Prograf2Open-labelMulticenterInternational89YY3
Frei 2010 (SP to Demirbas 2009)Prograf4Open-labelMulticenterInternational1645YN4
Gaston 2009Prograf4Open-labelMulticenterNorth America720YY3
Hamdy 2008PrografSingle-centerAfrica132YY2
Harland 2019Prograf2aOpen-labelMulticenterNorth America149YY3
Huh 2017Advagraf4Open-labelMulticenterEast Asia158YN2
Kramer 2010aPrograf3Open-labelMulticenterEurope451YY3
Kramer 2010bAdvagraf, Prograf3Mixed# MulticenterInternational676YY2
Kramer 2012 (SP to Kramer 2010a)Prograf3Open-labelMulticenterEurope451YY3
Langer 2012Prograf3Open-labelMulticenterInternational228YY2
Liu 2015PrografOpen-labelSingle-centerAsia72YY2
Tedesco-Silva 2014Astagraf (Advagraf), Prograf3Open-labelMulticenterInternational668YY3
Tsuchiya 2013Graceptor (Advagraf), PrografOpen-labelMulticenterAsia102YY2
* Region refers to the geographical region identified based on the study locations and could be any of either Africa, Asia, East Asia, Europe, North America, South America, or International if the study was carried out in multiple regions across the world.
# Kramer 2010b used a mixed approach that comprised an initial double-blind, double-dummy phase followed by an open-label observation period post-transplant.
CA – conference abstract; N – no; SP – secondary publication; TAC – tacrolimus; Y – yes.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358