Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

29 December 2021: Meta-Analysis

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

T A Manjunatha 1ABCDEF* , Rebecca Chng 1ABCDEF , Wai-Ping Yau 2ADE

DOI: 10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

Table 2 Key baseline characteristics among primary publications of studies in which 1 or more of the treatment arms used Advagraf or Prograf.

StudyTreatment armNMean age, yearsFemale, %Mean BMI, kg/m2Diabetes, %White, %Black, %Asian, %
Albano 2013TAC BID+MPA+CS30950.8031.725.495.82.31.9
TAC QD_0.20+MPA+CS30250.731.825.894.04.61.3
TAC QD_0.30+MPA+CS30450.232.925.595.72.32
TAC QD_0.20+MPA+CS (+BAS)28349.334.625.
Anutrakulchai 2019TAC BID_0.10+MPA+CS6340.6831.7100
TAC BID_0.08–0.125+MPA+CS6241.7740.3100
Arns 2017TAC BID (TacHexal)+MPA+CS3547.917.127.694.3
TAC BID (Prograf)+MPA+CS3847.223.726.094.7
Asher 2014SRL QD+MPA+CS1949 (median)
TAC BID+MPA+CS1949 (median)
Bakr 2018TAC BID+MPA+CS6629.3636.36
TAC QD+MPA+CS3329.8836.36
Chen 2008CsA BID+SRL QD+CS2040.265.00100
TAC BID+SRL QD+CS2142.776.19100
Cockfield 2019TAC QD_Low+ACEi/ARB7150.533.827.678.9
TAC QD_Low+OAH6948.030.427.375.4
TAC QD_Std+ACEi/ARB7150.433.828.381.7
TAC QD_Std+OAH7052.43027.081.4
De Graav 2017MPA+CS203085.010.05
TAC BID+MPA+CS2020.080.01010
Demirbas 2009CsA BID_Std+MPA+CS39045.937.76.992.12.11.3
CsA BID_Low+MPA+CS39947.
TAC BID_Low+MPA+CS40145.434.28.594.01.00.7
SRL QD_Low+MPA+CS39944.933.37.894.21.30.5
Ferguson 2011MPA+CS3349.2024.0073.024.0
SRL QD+CS2652.7023.0089.012.0
TAC BID+MPA+CS3053.6027.0077.017.0
Gaston 2009CNI_Low+MPA_Controlled+CS24348.332.965.826.7
Hamdy 2008SRL QD+MPA+CS6731.829.9
TAC BID+SRL QD+CS6532.320.0
Harland 2019TAC BID+MPA+CS4952.832.729.273.520.44.1
TAC BID+BLES+CS4452.431.828.670.5254.5
Huh 2017TAC QD+MPA+CS7546.0029.3022.5
TAC QD+SRL QD+CS7646.1025.0023.0
Kramer 2010aTAC BID15343.237.9
TAC BID+MPA15143.934.4
TAC BID+MPA+CS14743.238.8
Kramer 2010bTAC BID+MPA+CS33645.5036.0081.35.72.1
TAC QD+MPA+CS33144.9038.4083.74.21.5
Langer 2012TAC BID_1.5–3 ng/mL+EVR BID+CS10744.644.983.25.60
TAC BID_4–7 ng/mL+EVR BID+CS11746.94183.80.91.7
Liu 2015CsA BID+MPA+CS3643.0027.7822.1100
TAC BID+MPA+CS3642.0030.5621.8100
Tedesco-Silva 2014CsA BID+MPA+CS21247.638.727.476.917.03.8
TAC BID+MPA+CS21248.635.828.371.724.12.4
TAC QD+MPA+CS21447.835.523.474.819.22.3
Tsuchiya 2013TAC BID+MPA+CS5246.1032.70
TAC QD+MPA+CS5047.5032.00
ACEi/ARB – angiotensin-converting enzyme inhibitor/angiotensin II receptor 1 blocker; BAS – basiliximab; BID – twice daily; BLES – bleselumab; BMI – body mass index; CNI – calcineurin inhibitor; CS – corticosteroid; CsA – cyclosporin A; EVR – everolimus; MPA – mycophenolic acid; OAH – other antihypertensive; QD – once daily; SRL – sirolimus; Std – standard dose; TAC – tacrolimus.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358