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29 December 2021: Meta-Analysis

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

T A Manjunatha 1ABCDEF* , Rebecca Chng 1ABCDEF , Wai-Ping Yau 2ADE

DOI: 10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

Table 5 Patient death among all included studies in which 1 or more of the treatment arms used Advagraf or Prograf.

StudyPopulationTime pointTreatment armsNPatient death, nPatient death, %
Anutrakulchai 2019ITT6 monthsTAC BID_0.08–0.125+MPA+CS6258.1
ITT6 monthsTAC BID_0.10+MPA+CS6311.6
Arns 2017ITT6 monthsTAC BID (Prograf)+MPA+CS3812.6
ITT6 monthsTAC BID (TacHexal)+MPA+CS3500
Arriola 2018 (CA)72 monthsTAC BID+MPA+SRL+CS14.5
72 monthsTAC QD+MPA+EVR+CS13.4
Chen 2008ITT12 monthsCsA BID+SRL QD+CS2000
ITT12 monthsTAC BID+SRL QD+CS2100
Cockfield 2019ITT24 monthsTAC QD_Low+ACEi/ARB7100
ITT24 monthsTAC QD_Low+OAH6922.9
ITT24 monthsTAC QD_Std+ACEi/ARB7100
ITT24 monthsTAC QD_Std+OAH7011.4
De Graav 2017ITT12 monthsMPA+CS2000
ITT12 monthsTAC BID+MPA+CS2015.0
Ekberg 2010 (SP)ITT12 monthsCsA BID_Low+MPA+CS39951.3
ITT12 monthsCsA BID_Std+MPA+CS39082.1
ITT12 monthsSRL QD_Low+MPA+CS39961.5
ITT12 monthsTAC BID_Low+MPA+CS40192.2
Ferguson 2011ITT12 monthsMPA+CS3313.0
ITT12 monthsSRL QD+CS2600
ITT12 monthsTAC BID+MPA+CS3000
Gaston 2009ITT12 monthsCNI_Low+MPA_Controlled+CS24341.6
ITT12 monthsCNI_Std+MPA_Controlled+CS23720.8
ITT12 monthsCNI_Std+MPA_Fixed+CS24062.5
Hamdy 2008ITT36 monthsSRL QD+MPA+CS6711.5
ITT36 monthsTAC BID+SRL QD+CS6546.2
Harland 2019FASThrough 36 monthsBLES+MPA+CS4624.3
FASThrough 36 monthsTAC BID+BLES+CS4424.5
Huh 2017ITT12 monthsTAC QD+MPA+CS7500
ITT12 monthsTAC QD+SRL QD+CS7611.3
Kramer 2010aFAS12 monthsTAC BID15310.7
FAS12 monthsTAC BID+MPA15121.3
FAS12 monthsTAC BID+MPA+CS14700
Kramer 2010bITT12 monthsTAC BID+MPA+CS33682.4
ITT12 monthsTAC QD+MPA+CS331103.0
PP12 monthsTAC BID+MPA+CS29131.0
PP12 monthsTAC QD+MPA+CS28031.1
Kramer 2012 (SP)ITT36 monthsTAC BID14353.5
ITT36 monthsTAC BID+MPA13921.4
ITT36 monthsTAC BID+MPA+CS13953.6
Langer 2012ITT12 monthsTAC BID_1.5–3 ng/mL+EVR BID+CS10732.8
ITT12 monthsTAC BID_4–7 ng/mL+EVR BID+CS11732.6
ITT4–12 monthsTAC BID_1.5–3 ng/mL+EVR BID+CS10722.7
ITT4–12 monthsTAC BID_4–7 ng/mL+EVR BID+CS11711.1
Liu 2015ITT15 monthsCsA BID+MPA+CS3600
ITT15 monthsTAC BID+MPA+CS3612.8
Tedesco-Silva 2014FAS48 monthsCsA BID+MPA+CS212157.1
FAS48 monthsTAC BID+MPA+CS212167.5
FAS48 monthsTAC QD+MPA+CS214136.1
Tsuchiya 2013ITT12 monthsTAC BID+MPA+CS5200
ITT12 monthsTAC QD+MPA+CS5000
ACEi/ARB – angiotensin-converting enzyme inhibitor/angiotensin II receptor 1 blocker; BLES – bleselumab; BID – twice daily; CA – conference abstract; CNI – calcineurin inhibitor; CS – corticosteroid; CsA – cyclosporin A; EVR – everolimus; FAS – full analysis set; ITT – intention-to-treat; MPA – mycophenolic acid; OAH – other antihypertensive; PP – per-protocol; QD – once daily; SP – secondary publication; SRL – sirolimus; Std – standard dose; TAC – tacrolimus.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358