Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

01 December 2021: Original Paper

Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d Antibody-Mediated Rejection in Kidney Transplant Recipients

Vasishta S. Tatapudi 1*BDEF# , Dessislava Kopchaliiska 2ABC* , Gilberto J. da Gente 2C , Owen F. Buenaventura 2BC , Manpreet Singh 1BC$ , Zoltan Laszik 3BC , Deborah B. Adey 1CDE , Raja Rajalingam 2ADEF*

DOI: 10.12659/AOT.934175

Ann Transplant 2021; 26:e934175

Table 3 Kidney transplant recipients with de novo donor-specific HLA antibodies (dnDSA) of IgG MFI ≥5000 but negative for C3d and C1q-binding. The median fluorescence intensity (MFI) of each dnDSA is given in parenthesis.

RecipientSexRe-Tx# DSAHighest MFI dnDSAAdditional dnDSA (MFI)C4dRejection
1FNo2DQ5 (11056)DQ2 (6345)+cAMR
2MNo1DQ6 (8784)cAMR
3MYes3B35 (8576)B7 (6429), DR11 (1317)+aAMR
4MYes1DQ7 (8444)ACR
5FNo2DQ7 (8357)DQ8 (7273)+aAMR
6FNo1DQ7 (7851)No
7FNo1DQ4 (7706)No
8FYes3DR4 (7407)B55 (2334), DQ8 (3374)ACR
9MNo1DQ7 (7096)cAMR
10MNo5B39 (6383)A24 (1973), B35 (2742), Cw4 (5271), Cw7 (2562)ACR
11MNo1B44 (5971)No
12MNo5A2 (5277)A3 (2462), B48 (5209), DR8 (1428), DR11 (1360)+aAMR
13FNo4A2 (5218)B8 (5161), B60 (1683), Cw3 (2105)+cAMR
14MNo1DQ7 (5188)No
15MNo2DQ5 (5089)DR14 (3759)ACR
16MNo2DQ4 (5058)DR53 (1931)No

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358