26 January 2022 : Review article
Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models
Wojciech Andrzej Straś1AEF, Dariusz Wasiak1F, Beata Łągiewska2F, Olga Tronina3EF*, Marta Hreńczuk1F, Joanna Gotlib4F, Wojciech Lisik2AF, Piotr Małkowski1AEFGDOI: 10.12659/AOT.934924
Ann Transplant 2022; 27:e934924
Table 1 Risk factors predicting hepatocellular carcinoma before and after liver transplantation.
Risk factors | Ref. | |
---|---|---|
Risk factors before transplantation | ✓ Numer and size of the nodules | [,,]19 |
✓ Vascular invasion | [,]11 | |
✓ Alpha-Fetoprotein level | [,,]27 | |
✓ Neutrophil-lymphocyte ratio | [,,,–]19 | |
✓ Positron emission tomography scan/magnetic resonance imaging | [,–]19 | |
✓ Bridging therapy response | [,,,–]8 | |
✓ Metabolic syndrome, obesity | [–]54 | |
✓ HBV and HCV viral infections | [–]64 | |
✓ Biopsy | [–]85 | |
✓ Time to transplantation | 17, 88–89 | |
Post-transplantation risk factors | ✓ Degree of tumor differentiation, vascular invasion | [,–]11 |
✓ Liver donor | [–]92 | |
✓ Cold ischemia time | [–]96 | |
✓ Operating technique | [,]99 | |
✓ Immunosuppression | [–]101 | |
✓ Adjuvant treatment | [,–]21 |