Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

Wojciech Andrzej Straś; Dariusz Wasiak; Beata Łągiewska; Olga Tronina; Marta Hreńczuk; Joanna Gotlib; Wojciech Lisik; Piotr Małkowski

doi:10.12659/AOT.934924

26 January 2022: Review Paper

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

Wojciech Andrzej Straś ^1AEF , Dariusz Wasiak ^1F , Beata Łągiewska ^2F , Olga Tronina ^3EF* , Marta Hreńczuk ^1F , Joanna Gotlib ^4F , Wojciech Lisik ^2AF , Piotr Małkowski ^1AEFG

DOI: 10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

Authors information Article notes Copyright and License information

Background Risk Factors Before Procedure Post-Transplantation Risk Factors Recurrence Risk Stratification Models Surveillance, Treatment of Recurrence Conclusions References

View HTML version

Table 1 Risk factors predicting hepatocellular carcinoma before and after liver transplantation.

	Risk factors	Ref.
Risk factors before transplantation	✓ Numer and size of the nodules	[,,]¹⁹
	✓ Vascular invasion	[,]¹¹
	✓ Alpha-Fetoprotein level	[,,]²⁷
	✓ Neutrophil-lymphocyte ratio	[,,,–]¹⁹
	✓ Positron emission tomography scan/magnetic resonance imaging	[,–]¹⁹
	✓ Bridging therapy response	[,,,–]⁸
	✓ Metabolic syndrome, obesity	[–]⁵⁴
	✓ HBV and HCV viral infections	[–]⁶⁴
	✓ Biopsy	[–]⁸⁵
	✓ Time to transplantation	17, 88–89
Post-transplantation risk factors	✓ Degree of tumor differentiation, vascular invasion	[,–]¹¹
	✓ Liver donor	[–]⁹²
	✓ Cold ischemia time	[–]⁹⁶
	✓ Operating technique	[,]⁹⁹
	✓ Immunosuppression	[–]¹⁰¹
	✓ Adjuvant treatment	[,–]²¹

Back to the Article

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

Your Privacy