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24 May 2022: Review Paper

A Systematic Review of the Literature on Chronic Kidney Disease Following Liver Transplantation

Hitomi Miyata 1ADE* , Yoshiaki Morita 2ADE , Anil Kumar 3DE

DOI: 10.12659/AOT.935170

Ann Transplant 2022; 27:e935170

Supplementary Table 2 Incidence or prevalence of diabetes for the included studies.

Author, year [ref]Study armnDefinition of diabetesTimepointPopulation, nIncidence or prevalence of diabetes, n (%)
Gojowy D et al, 2020 []24 130Based on medical recordsBaseline63 (48.5)
Levitsky J et al, 2020 []25 28Baseline (at transplantation)7 (25.0)
32Baseline (at transplantation)7 (21.9)
Lladó L et al, 2019 []26 69Pre transplantation: clinical history. NODM: use of insulin for >30 consecutive days, plasma glucose ≥200 mg/dL with diabetes symptoms, fasting plasma glucose ≥126 mg/dL, and/or fasting plasma glucose >200 mg/dL after 75 g glucose challengeBaseline15 (21.7)
12 months (NODM)19 (27.5)
Jochmans I et al, 2017 []28 21Baseline4 (19.0)
59Baseline12 (20.3)
Dopazo C et al, 2018 []29 20Baseline10 (50.0)
Pascher A et al, 2015 []30 49NODM assumed if: two consecutive fasting plasma glucose ≥7.0 mmol/L after day 30, or HbA1c >6.5% (from day 75 onward)6 monthsSAF, 4813 (40.6)
516 monthsSAF, 5317 (42.5)
496 monthsSAF, 4513 (41.9)
516 monthsSAF, 5216 (38.1)
Sharma P et al, 2019 []7 93Baseline33 (35.5)
Lim Y-T et al, 2020 []19 78Fasting glycemia repeatedly >126 mg/dL, glycated hemoglobin ≥6.5% or oral hypoglycemic or insulin treatment (based on WHO criteria)Baseline7515 (20.0)
6 months (NODM)535 (9.4)
Saliba F et al, 2017 []22 93Fasting glycemia ≥126 mg/dL and/or treatment with a hypoglycemic agentBaselineRandomized26 (28.0)
95BaselineRandomized28 (29.5)
Chauhan KC et al, 2018 []20 290Baseline29096 (33.1)
223Baseline22367 (30.0)
67Baseline6729 (43.3)
149Baseline14940 (26.9)
141Baseline14156 (39.7)
AKI – acute kidney injury; ATG – anti-human T-lymphocyte globulin; BID – twice daily; CKD – chronic kidney disease; CsA – ciclosporin A; EC-MPS – enteric-coated mycophenolate sodium; eGFR – estimated glomerular filtration rate; HbA1c – hemoglobin A1c; MMF – mycophenolate mofetil; NODM – new-onset diabetes mellitus; OLT – orthotopic liver transplantation; QD – once daily; SAF – safety analysis set; TAC – tacrolimus.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358