24 May 2022 : Review article
A Systematic Review of the Literature on Chronic Kidney Disease Following Liver Transplantation
Hitomi Miyata1ADE*, Yoshiaki Morita2ADE, Anil Kumar3DEDOI: 10.12659/AOT.935170
Ann Transplant 2022; 27:e935170
Background
Protocol and Registration
Eligibility Criteria and Study Selection Process
Information Sources and Search Strategy
Data Collection Process and Summary Measures
Data Items and Outcomes
Risk of Bias in Individual Studies
Grading of Included Studies
Study Selection
Baseline Characteristics
Immunosuppressive Treatment
Renal Function
CKD Incidence/Prevalence and Stage
Patient and Graft Survival
Graft Rejection
Diabetes
Risk of Bias Across Studies
Discussion
Conclusions
References
Table 7 Patient deaths for the included studies.
| Author, year [ref] | Study arm | n | Timepoint | Population, n | Patient deaths, n (%) |
|---|---|---|---|---|---|
| Chen WY et al, 2017 []23 | 14 | 18 months | – | 0 | |
| 28 | 18 months | – | 0 | ||
| Lladó L et al, 2019 []26 | 69 | 12 months | – | 3 (4.3) | |
| Hong S et al, 2017 []27 | 48 | 6 months | – | 0 | |
| Jochmans I et al, 2017 []28 | 21 | 12 months | – | 2 (9.5) | |
| 59 | 12 months | – | 1 (1.7) | ||
| Dopazo C et al, 2018 []29 | 20 | 12 months | – | 1 (5.0) | |
| Pascher A et al, 2015 []30 | 49 | 6 months | FAS, 49 | 7 (14.3) | |
| 51 | 6 months | FAS, 51 | 3 (5.9) | ||
| 49 | 6 months | FAS, 49 | 4 (8.2) | ||
| 51 | 6 months | FAS, 51 | 1 (2.0) | ||
| Sharma P et al, 2019 []7 | 93 | Last follow-up (median 4 years) | – | 17 (18.3) | |
| Lim Y-T et al, 2020 []19 | 78 | 6 months | – | 3 (3.8) | |
| Saliba F et al, 2017 []22 | 93 | 6 months | ITT, 90 | 1 (1.1) | |
| 95 | 6 months | ITT, 93 | 1 (1.1) | ||
| Chauhan KC et al, 2018 []20 | 290 | 12 months | 290 | 35 (12.1) | |
| 24 months | 43 (14.8) | ||||
| 223 | 12 months | 223 | 20 (9.0) | ||
| 24 months | 26 (11.7) | ||||
| 67 | 12 months | 67 | 15 (22.4) | ||
| 24 months | 17 (25.4) | ||||
| 149 | 12 months | 149 | 7 (4.7) | ||
| 24 months | 10 (6.7) | ||||
| 141 | 12 months | 141 | 28 (19.9) | ||
| 24 months | 33 (23.4) | ||||
| AKI – acute kidney injury; ATG – anti-human T-lymphocyte globulin; BID – twice daily; CKD – chronic kidney disease; EC-MPS – enteric-coated mycophenolate sodium; FAS – full analysis set; ITT – intention-to-treat; MMF – mycophenolate mofetil; OLT – orthotopic liver transplantation; QD – once daily; TAC – tacrolimus. | |||||