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29 March 2022: Database Analysis

Bioinformatics Identification of Candidate Biomarkers in Endomyocardial Biopsy and Peripheral Blood for Cardiac Allograft Rejection

Kang Luo 1ABCDEFG , Lin Li 2BCDE , Mingyao Meng 2DEFG , Yan Chen 1BC , Zongliu Hou 2EF

DOI: 10.12659/AOT.935488

Ann Transplant 2022; 27:e935488

Table 3 Enrichment of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of significance for differentially expressed genes (DEGs) from endomyocardial biopsy samples.

GOTERM_MFGO: 0005515Protein binding570.01841913
GOTERM_MFGO: 0042803Protein homodimerization activity100.013700626
GOTERM_MFGO: 0042802Identical protein binding120.00173391
GOTERM_MFGO: 0005102Receptor binding111.49E-05
GOTERM_CCGO: 0016021Integral component of membrane390.00321182
GOTERM_CCGO: 0005794Golgi apparatus100.026519452
GOTERM_CCGO: 0005886Plasma membrane340.001736587
GOTERM_CCGO: 0070062Extracellular exosome283.47E-04
GOTERM_CCGO: 0005887Integral component of plasma membrane211.46E-05
GOTERM_CCGO: 0016020Membrane210.004716471
GOTERM_CCGO: 0005576Extracellular region197.84E-04
GOTERM_CCGO: 0005615Extracellular space182.82E-04
GOTERM_CCGO: 0006955Immune response176.07E-10
GOTERM_CCGO: 0000139Golgi membrane116.63E-04
GOTERM_BPGO: 0045087Innate immune response132.72E-06
GOTERM_BPGO: 0009986Cell surface131.41E-05
GOTERM_BPGO: 0007165Signal transduction120.042676364
GOTERM_BPGO: 0050852T cell receptor signaling pathway108.77E-08
GOTERM_BPGO: 0006954Inflammatory response101.79E-04
KEGG_PATHWAYhsa04612Antigen processing and presentation124.60E-11
KEGG_PATHWAYhsa05168Herpes simplex infection125.45E-07
KEGG_PATHWAYhsa04514Cell adhesion molecules (CAMs)104.23E-06
KEGG_PATHWAYhsa05164Influenza A102.21E-05
The criteria are count ≥10 and value

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358