29 March 2022: Database Analysis
Bioinformatics Identification of Candidate Biomarkers in Endomyocardial Biopsy and Peripheral Blood for Cardiac Allograft Rejection
Kang Luo 1ABCDEFG , Lin Li 2BCDE , Mingyao Meng 2DEFG , Yan Chen 1BC , Zongliu Hou 2EFDOI: 10.12659/AOT.935488
Ann Transplant 2022; 27:e935488
Table 4 Enrichment of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of significance for differentially expressed genes (DEGs) from peripheral blood samples.
| Category | Term | Description | Count | p-Value |
|---|---|---|---|---|
| GOTERM_MF_ | GO: 0005515 | Protein binding | 114 | 1.90E-06 |
| GOTERM_MF_ | GO: 0044822 | poly(A) RNA binding | 19 | 0.022148293 |
| GOTERM_MF_ | GO: 0042803 | Protein homodimerization activity | 16 | 0.004263137 |
| GOTERM_CC_ | GO: 0005737 | Cytoplasm | 66 | 0.006773839 |
| GOTERM_CC_ | GO: 0005829 | Cytosol | 55 | 2.23E-05 |
| GOTERM_CC_ | GO: 0016020 | Membrane | 33 | 0.008967662 |
| GOTERM_CC_ | GO: 0005622 | Intracellular | 23 | 0.007774602 |
| GOTERM_CC_ | GO: 0005741 | Mitochondrial outer membrane | 6 | 0.013942611 |
| GOTERM_CC_ | GO: 0005840 | Ribosome | 6 | 0.021196797 |
| GOTERM_CC_ | GO: 0045121 | Membrane raft | 6 | 0.046903966 |
| GOTERM_BP_ | GO: 0035556 | Intracellular signal transduction | 11 | 0.006858197 |
| GOTERM_BP_ | GO: 0043066 | Negative regulation of apoptotic process | 10 | 0.03717623 |
| GOTERM_BP_ | GO: 0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 6 | 0.006570574 |
| GOTERM_BP_ | GO: 0006413 | Translational initiation | 6 | 0.011674787 |
| GOTERM_BP_ | GO: 0000209 | Protein polyubiquitination | 6 | 0.03611137 |
| GOTERM_BP_ | GO: 0006661 | Phosphatidylinositol biosynthetic process | 5 | 0.002580151 |
| GOTERM_BP_ | GO: 0006614 | SRP-dependent cotranslational protein targeting to membrane | 5 | 0.014114136 |
| GOTERM_BP_ | GO: 0019083 | Viral transcription | 5 | 0.025108741 |
| The criteria are count ≥5 and value | ||||