Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

05 April 2022: Original Paper

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

Okjoo Lee 1ABCDEF , Jinsoo Rhu 1ABCDE* , Gyu-Seong Choi 1ABCDE , Jong Man Kim 1CD , Kyunga Kim 2CD , Jae-Won Joh 1CD

DOI: 10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

Table 2 Postoperative outcomes.

CharacteristicsStatin non-user (n=334)Statin user (n=52)P-value
Donor fatty change (%)
Graft weight (g)699.10±128.47727.96±120.770.064
Operation time (min)563.89±113.08553.02±105.910.455
Cold ischemic time (min)88.90±29.18102.40±64.960.981
Warm ischemic time (min)35.13±14.4733.31±11.720.492
 Size (largest, cm)3.03±1.992.58±1.600.094
 Pathologic (Edmonson grade)2.02±0.501.88±0.550.080
 Microvascular invasion169 (50.60%)23 (44.23%)0.393
Postoperative laboratory findings (at 7 days after LT)
 Peak AST (U/L)368.02±399.98463.56±507.850.012
 Peak ALT (U/L)395.71±433.17461.56±363.760.015
 Peak total bilirubin (mg/dL)4.10±4.544.25±6.260.359
 Pear prothrombin time (INR)2.65±0.672.52±0.630.098
Acute rejection episode38 (11.38%)11 (21.15%)0.049
Complication (Clavien-Dindo)167 (50.0%)24 (46.15%)0.606
Recurrence108 (32.34%)5 (9.62%)
Death113 (34.24%)3 (5.36%)
 HCC recurrence related692
GRWR – graft-recipient weight ratio; AST – aspartate aminotransferase; ALT – alanine aminotransferase; INR – international normalized ratio.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358